Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Common European MRSA originated in Africa

26.08.2014

The predominant strain of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infecting people in Europe, the Middle East and northern Africa derived from a single sub-Saharan ancestor, a team of international researchers reported this week in mBio®, the online open-access journal of the American Society for Microbiology.

CA-MRSA refers to MRSA infections occurring in healthy people with no recent hospitalizations. The infections, which are typically skin infections, can be transmitted through close person-to-person contact or contact with a contaminated item like a towel or clothing.

"With increasing levels of CA-MRSA reported from most parts of the Western world, there is a great interest in understanding the origin and factors associated with the emergence of these epidemic lineages," said lead study author Marc Stegger, PhD, of the Department of Microbiology and Infection Control at the Statens Serum Institut in Denmark. "Our study determined that a single descendant of a methicillin-sensitive ancestor circulating in sub-Saharan Africa rose to become the dominant CA-MRSA clone in Europe, the Middle East and north Africa."

In Europe, the predominant CA-MRSA strain belongs to a family called clonal complex 80 (CC80), which are resistant to the antibiotics kanamycin/amikacin, tetracyclin and fusidic acid, in addition to beta-lactams. It was first identified sporadically in the late 1990s, but has since been identified throughout northern Africa, the Middle East and Europe, with only sporadic reports from Asia, Australia and South America.

For the study, Stegger and colleagues at 19 other institutions around the world analyzed 97 S. aureus CC80 samples from 22 countries in Europe, North Africa, sub-Saharan Africa, the Middle East and Asia isolated between 1993 and 2010. Twenty-three samples were sensitive to methicillin while 74 were resistant to methicillin. The investigators performed whole genome sequencing, a technique that determines the complete DNA sequence of an organism's genetic material at a single time, and other tests to trace the origin, evolution and dissemination pattern of the European CA-MRSA clone CC80.

Within the samples, the team identified two distinct groups of S. aureus: a methicillin-sensitive clone from sub-Saharan Africa that was susceptible to all antibiotics, and the rest from all other areas that were MRSA and most often resistant to other antibiotics. Studying family trees among the bacteria, they found that the European CC80 clone evolved from the strain from sub-Saharan Africa. They also noted that in the transition from a methicillin-sensitive line to a CA-MRSA clone, the bacteria simultaneously acquired two highly specific genetic elements making them resistant to methicillin and became resistant to fusidic acid.

The methicillin-sensitive S. aureus resided in sub-Saharan Western Africa, potentially as a result of the local human migration patterns, Stegger said. The investigators hypothesize that CC80 moved to other countries starting in the mid-1980s due to several factors, including increased migration from sub-Saharan Africa in search of better economics, and as a result of an increase in European tourism to this region of Africa, he said. The simultaneous acquisition of methicillin and fusidic acid resistance determinants and their stability in the European CA-MRSA could be a result of a higher selective pressure in North Africa and Europe.

###

The study was supported by Pfizer and the Foundation pour la Recherche Médicale.

mBio® is an open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mbio.asm.org.

The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.

Jim Sliwa | Eurek Alert!
Further information:
http://www.asmusa.org

Further reports about: Africa CA-MRSA MRSA acid antibiotics aureus bacteria infections investigators microbiology strain sub-Saharan

More articles from Studies and Analyses:

nachricht Study suggests new way of preventing diabetes-associated blindness
26.05.2015 | Johns Hopkins Medicine

nachricht Memories Influence Choice of Food
22.05.2015 | Universität Basel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Solid-state photonics goes extreme ultraviolet

Using ultrashort laser pulses, scientists in Max Planck Institute of Quantum Optics have demonstrated the emission of extreme ultraviolet radiation from thin dielectric films and have investigated the underlying mechanisms.

In 1961, only shortly after the invention of the first laser, scientists exposed silicon dioxide crystals (also known as quartz) to an intense ruby laser to...

Im Focus: Advance in regenerative medicine

The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.

Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...

Im Focus: Basel Physicists Develop Efficient Method of Signal Transmission from Nanocomponents

Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.

Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...

Im Focus: IoT-based Advanced Automobile Parking Navigation System

Development and implementation of an advanced automobile parking navigation platform for parking services

To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...

Im Focus: First electrical car ferry in the world in operation in Norway now

  • Siemens delivers electric propulsion system and charging stations with lithium-ion batteries charged from hydro power
  • Ferry only uses 150 kilowatt hours (kWh) per route and reduces cost of fuel by 60 percent
  • Milestone on the road to operating emission-free ferries

The world's first electrical car and passenger ferry powered by batteries has entered service in Norway. The ferry only uses 150 kWh per route, which...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International symposium: trends in spatial analysis and modelling for a more sustainable land use

20.05.2015 | Event News

15th conference of the International Association of Colloid and Interface Scientists

18.05.2015 | Event News

EHFG 2015: Securing health in Europe. Balancing priorities, sharing responsibilities

12.05.2015 | Event News

 
Latest News

Siemens will provide the first H-class power plant technology in Mexico

28.05.2015 | Press release

Merging galaxies break radio silence

28.05.2015 | Physics and Astronomy

A New Kind of Wood Chip: Collaboration Could Yield Biodegradable Computer Chips

28.05.2015 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>