Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Colonoscopy linked to decrease in colorectal cancer deaths, but many more could have been prevented

09.03.2011
New Study Appears in the March GIE: Gastrointestinal Endoscopy Special Issue on Colonoscopy and Colorectal Cancer

In recognition of National Colorectal Cancer Awareness Month during March, GIE: Gastrointestinal Endoscopy has published a special issue for March on colonoscopy and colorectal cancer.

The issue includes a study showing that colonoscopy has prevented a substantial number of deaths from colorectal cancer and that many more could have been prevented with more widespread use. The analysis reports that approximately 13,800 to 22,000 colorectal cancer deaths could have been prevented in 2005, whereas 7,300 to 11,700 were actually prevented through colonoscopy use. GIE: Gastrointestinal Endoscopy is the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

"March 2011 marks the twelfth annual National Colorectal Cancer Awareness Month. Numerous efforts are made nationwide to increase patient knowledge regarding colorectal cancer, increase screening efforts and lifestyle changes to reduce risk. As gastroenterologists and practicing endoscopists, much of our daily efforts revolve around screening, diagnosis, and treatment for this malignancy. Therefore, GIE is devoting this issue to topics germane to these endeavors," said GIE Editor Glenn M. Eisen, MD, MPH, FASGE. "Among the important studies in this special issue is research reporting that a substantial number of colorectal cancer deaths have been prevented through the use of colonoscopy, however, many more deaths could have been prevented with more widespread use of this screening method. Colonoscopy can be an effective tool to reduce mortality rates from this largely preventable disease, but we still have a long way to go in getting more people screened for colorectal cancer."

"Colorectal cancer mortality prevented by use and attributable to nonuse of colonoscopy"

Colonoscopy has contributed to decreasing mortality rates and it is now the predominant tool for colorectal cancer screening in the United States. Results from national health surveys indicate that approximately half of the population eligible for colorectal cancer screening has had either a colonoscopy or sigmoidoscopy in the past ten years. To date, the effectiveness of the use of colonoscopy in reducing colorectal cancer-related mortality has only been directly shown in epidemiological studies. The effectiveness of colonoscopy use is indirectly supported by studies that showed decreases in colorectal cancer mortality associated with sigmoidoscopy and by studies that observed decreases in colorectal cancer incidence associated with removal of adenomatous (precancerous) polyps as well as with colonoscopy in general.

The aim of this study was to estimate the impact of current colonoscopy use on colorectal cancer mortality and the further potential of colonoscopy to reduce colorectal cancer mortality in the U.S. population by assuming effectiveness as reported in published epidemiological studies. Data from three sources were combined to perform the analysis. Data on history of colonoscopy use were obtained from the National Health Interview Survey; data on colorectal cancer mortality and on population sizes were drawn from the Surveillance, Epidemiology, and End Results program database; and estimates of the effectiveness of colonoscopy were derived from the medical literature. The year 2005 was the latest for which mortality data and suitable colonoscopy use were available. The study was limited to the population aged 50 years and older, which reflects the screening-eligible age.

A statistical analysis was performed and showed that approximately 13,800 to 22,000 colorectal cancer deaths (depending on the assumed effectiveness) could have been prevented in 2005, whereas about 7,300 to 11,700 were actually prevented through the use of colonoscopy. Therefore, approximately twice as many colorectal cancer deaths could have been prevented by colonoscopy than were actually prevented.

Other highlights from the March issue:

"The Colorectal Cancer Control Program: partnering to increase population level screening"

Researchers from the Centers for Disease Control and Prevention (CDC) authored a special article describing their work in extending screening for colorectal cancer prevention. In 2009, the CDC began a public health initiative—the Colorectal Cancer Control Program, which includes two components: a screening provision, supporting clinical service delivery for low income, under-insured persons; and screening promotion, involving activities to encourage broad, population-level screening. The article describes in detail their efforts to increase screening adherence to 80 percent of the population.

"Dynamic patient position changes during colonoscope withdrawal increase adenoma detection: a randomized, crossover trial"

Good colonoscopic withdrawal technique is associated with lower adenoma (precancerous polyp) miss rates and there has been a recent resurgence of research interest in elements of basic operator technique. Dynamic patient position changes during colonoscope withdrawal can improve luminal distension. In this study, researchers assessed whether position changes also improve polyp and adenoma detection, and the study concludes just that: dynamic position changes during colonoscope withdrawal significantly improved polyp and adenoma detection.

"Time of day variation in polyp detection rate for colonoscopies performed on a 3-hour shift schedule"

Recent research suggests that the colonoscopy polyp detection rate varies by time of day, possibly because of endoscopist fatigue. Mayo Clinic Rochester schedules colonoscopies in three-hour shifts, which should minimize fatigue. Researchers report that, at this institution, a three-hour shift schedule does not show a decrease in the polyp detection rate as the day progresses, as seen in other recent studies. Intervention trials at other institutions could determine whether alterations in shift length lead to polyp detection rate improvements.

About the American Society for Gastrointestinal Endoscopy

Since its founding in 1941, the American Society for Gastrointestinal Endoscopy (ASGE) has been dedicated to advancing patient care and digestive health by promoting excellence in gastrointestinal endoscopy. ASGE, with nearly 12,000 members worldwide, promotes the highest standards for endoscopic training and practice, fosters endoscopic research, recognizes distinguished contributions to endoscopy, and is the foremost resource for endoscopic education. Visit www.asge.org and www.screen4coloncancer.org for more information and to find a qualified doctor in your area.

About Endoscopy

Endoscopy is performed by specially-trained physicians called endoscopists using the most current technology to diagnose and treat diseases of the gastrointestinal tract. Using flexible, thin tubes called endoscopes, endoscopists are able to access the human digestive tract without incisions via natural orifices. Endoscopes are designed with high-intensity lighting and fitted with precision devices that allow viewing and treatment of the gastrointestinal system.

Anne Brownsey | EurekAlert!
Further information:
http://www.asge.org

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>