The study is published in the June 20, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
For the study, 159 people with Parkinson’s disease randomly assigned to deep brain stimulation of the globus pallidus interna (GPi) or subthalamic nucleus (STN) of the brain were followed for three years. Participants reported motor symptoms in a diary for 30 minutes every half hour for two days before each of the six study visits. Medication use was allowed in the study.
“Past studies have had mixed results about which area of the brain benefits the most from deep brain stimulation,” said study author Frances M. Weaver, PhD, with Hines Veterans Administration Hospital and Loyola University Stritch School of Medicine in Maywood, Ill. “In our study, deep brain stimulation of both areas improved motor symptoms by 32 percent on average over the course of three years. However, deep brain stimulation of the GPi region of the brain was associated with a slower decline in thinking skills. More research will help us to find out whether medication or the deep brain stimulation was responsible for these differences.”
The study does have one major limitation, according to accompanying editorial author Michele Tagliati, MD, with Cedars-Sinai Medical Center in Los Angeles and a Fellow of the American Academy of Neurology. “A fairly large amount, or about 50 percent, of the initial participants could not be observed at three years due to the original study design and timeline. However, these data provide more reliable evidence that the improvement of motor symptoms of Parkinson’s disease by deep brain stimulation remains stable over the long term regardless of the area in the brain in which the deep brain stimulation occurs,” said Tagliati.
The study was supported by the Cooperative Studies Program, the Department of Veterans Affairs Office of Research and Development and the National Institute of Neurological Disorders and Stroke with additional funding from Medtronic Neurological, Inc.
To learn more about Parkinson’s disease, visit http://www.aan.com/patients.
The American Academy of Neurology, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com
Rachel L. Seroka | American Academy of Neurology
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine