Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study suggests that circumcision can hinder infection and inflammation that may lead to this malignancy.
Infections are known to cause cancer, and research suggests that sexually transmitted infections may contribute to the development of prostate cancer. Also, certain sexually transmitted infections can be prevented by circumcision. Therefore, it stands to reason that circumcision should protect against the development of some cases of prostate cancer. This is what lead author Jonathan L. Wright, MD, an affiliate investigator in the Hutchinson Center's Public Health Sciences Division, and his colleagues set out to test.
For their study, the investigators analyzed information from 3,399 men (1,754 with prostate cancer and 1,645 without). Men who had been circumcised before their first sexual intercourse were 15 percent less likely to develop prostate cancer than uncircumcised men. This reduced risk applied for both less aggressive and more aggressive cancers. (Specifically, men circumcised before their first sexual intercourse had a 12 percent reduced risk for developing less aggressive prostate cancer and an 18 percent reduced risk for developing more aggressive prostate cancer.)
Sexually transmitted infections may lead to prostate cancer by causing chronic inflammation that creates a hospitable environment for cancer cells. Other mechanisms may also be involved. Circumcision may protect against sexually transmitted infections, and therefore prostate cancer, by toughening the inner foreskin and by getting rid of the moist space under the foreskin that may help pathogens survive.
"These data are in line with an infectious/inflammatory pathway which may be involved in the risk of prostate cancer in some men," said Dr. Wright, who is also an assistant professor of urology at the University of Washington School of Medicine. "Although observational only, these data suggest a biologically plausible mechanism through which circumcision may decrease the risk of prostate cancer. Future research of this relationship is warranted," he added.
Amy Molnar | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy