Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Childhood Cancer Survivors at Higher Risk for Future GI Complications

23.05.2011
Individuals who are treated for cancer during childhood have a significantly higher risk of developing gastrointestinal (GI) complications — from mild to severe — later in life, according to a study led by the University of California, San Francisco (UCSF).

The findings underscore the need for childhood cancer survivors and their physicians to be aware of these risk factors to ensure patients’ ongoing health care needs are met.

“We have, in a relatively short period of time, made remarkable progress in treating pediatric cancer, which has resulted in a growing population of childhood cancer survivors,” said lead author Robert Goldsby, MD, a pediatric cancer specialist at UCSF Benioff Children’s Hospital and director of the UCSF Survivors of Childhood Cancer Program. “While we know that many cancer therapies can cause gastrointestinal problems in patients at the time of treatment, this is the first major study to examine long-term GI complications in childhood cancer survivors.”

The study appears in the May 2011 issue of Gastroenterology, the official journal of the American Gastroenterological Association Institute. It is currently available online.

About one in 500 young adults in the United States is a survivor of childhood cancer. Using data from the multicenter Childhood Cancer Survivor Study, the researchers evaluated the frequency of self-reported GI problems in 14,358 patients who had been treated for different types of cancer — leukemia, brain tumors, lymphoma, Wilms tumor, neuroblastoma, sarcomas or bone tumors — and survived at least five years following treatment.

Study participants were diagnosed and treated between 1970 and 1986 at one of 26 collaborating institutions in the United States and Canada, with most patients younger than 10 years old at the time of diagnosis.

Overall, more than 40 percent of the cancer survivors reported experiencing some type of GI complication within 20 years after treatment. Additionally, the study indicated that patients who were diagnosed at an older age and who had undergone more intensive therapy, including radiation, chemotherapy and surgery, were more likely to develop long-term GI problems.

The researchers also compared the prevalence of GI disorders in the cancer survivors to a randomly selected group of the patients’ siblings and found that the survivors had a significantly higher risk of developing upper GI complications such as ulcers, esophageal disease, and indigestion; lower GIissues such as intestinal polyps, chronic diarrhea and colitis; and liver conditions such as cirrhosis, gallstones, and jaundice.

“While physicians continue to learn about the long-term consequences of pediatric cancer and its therapy, it is essential that we provide comprehensive follow-up care that appropriately addresses the complications cancer survivors may experience,” Goldsby said. “These are serious issues that can have a real impact on a person’s quality of life.”

Goldsby added that because the risks of late GI complications may change as therapy for childhood and adolescent cancer continues to evolve, studies of more recently treated patients will be needed.

The research was supported by a grant from the National Cancer Institute, with additional funding from the American Lebanese Syrian Associated Charities, the Campini Foundation, the Mount Zion Foundation, and Swim Across America.

Co-authors from UCSF are Shannon Raber, NP, and Linda Li, CRC. Additional co-authors include Yan Chen, and Yutaka Yasui, PhD, of the University of Alberta; Karen Diefenbach, MD, and Nina Kadan-Lottick, MD, MSPH, of the Yale University School of Medicine; Margarett Shnorhavorian, MD, MPH, of Seattle Children’s Hospital; Fay Kastrinos, MD, MPH, of Columbia University Medical Center; Marilyn Stovall, MPH, of the M.D Anderson Cancer Center; Kevin Oeffinger, MD, and Charles Sklar, MD, of Memorial Sloan-Kettering Cancer Center; and Greg Armstrong, MD, MSCE, and Leslie Robison, PhD, of St. Jude Children’s Research Hospital.

The UCSF Survivors of Childhood Cancer Program provides comprehensive services for pediatric cancer survivors and helps patients achieve optimal physical and emotional health through medical care, education and research. More information about the Program is available here.

UCSF Benioff Children’s Hospital creates an environment where children and their families find compassionate care at the forefront of scientific discovery, with more than 150 experts in 50 medical specialties serving patients throughoutNorthern California and beyond. The hospital admits about 5,000 children each year, including 2,000 babies born in the hospital.

Kate Vidinsky | EurekAlert!
Further information:
http://www.ucsf.edu

Further reports about: Cancer Childhood Complications UCSF childhood cancer risk factor

More articles from Studies and Analyses:

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Disarray in the brain
18.12.2017 | Universität zu Lübeck

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>