Research suggests that intelligence in humans is controlled by the part of the brain known as the 'cortex', and most theories of age-related cognitive decline focus on cortical dysfunction.
However, a new study of Scottish older adults, reported in the April 2011 issue of Elsevier's Cortex (http://www.sciencedirect.com/science/journal/00109452), suggests that grey matter volume in the 'cerebellum' at the back of the brain predicts cognitive ability, and keeping those cerebellar networks active may be the key to keeping cognitive decline at bay.
The study looked at 228 older adults living independently in the Aberdeen area, who had been part of the Scottish Mental Survey of 1947. This survey had tested Scottish children born in 1936 and at school on 4th June 1947 using the Moray House intelligence test. The cognitive abilities of the participants were tested again, now at age 63-65 years, and their brains were also scanned, using a neuroimaging technique called voxel-based morphometry (VBM), to determine the volumes of grey and white matter in frontal areas and the cerebellum.
The most interesting finding from this study is that grey matter volume in the cerebellum predicts general intelligence. However, results differ for men and women, with men showing a stronger relationship between brain volume in the cerebellum and general intelligence.
It has long been recognised that the cerebellum is involved in sensory-motor functions, including balance and timing of movements, but it is now believed that the cerebellum also plays an important role in higher-level cognitive abilities. "General intelligence is correlated with many basic aspects of information processing efficiency which I believe depend upon the functioning of the cerebellum, including the speed and consistency of our perceptions and decisions, and the speed with which we learn new skills", notes Dr. Michael Hogan, first author of the study. "This is exciting research, as it suggests that there may be a backdoor route into maintaining higher cortical functions in old age, that is, through the sustained activation of cerebellar networks via novel sensory-motor and cognitive activities, all of which I believe the cerebellum seeks to regulate and automate, working in concert with the cortex."
Notes to Editors:
The article is "Cerebellar brain volume accounts for variance in cognitive performance in older adults" by Michael J. Hogan, Roger T. Staff, Brendan P. Bunting, Alison D. Murray, Trevor S. Ahearn, Ian J. Deary, and Lawrence J. Whalley, and appears in Cortex, Volume 47, Issue 4 (April 2011), published by Elsevier in Italy. Full text of the article featured above is available to members of the media upon request. Please contact the Elsevier press office, firstname.lastname@example.org. To schedule an interview, contact Dr Michael Hogan, email@example.com.
Cortex is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi. The Editor in-chief of Cortex is Sergio Della Sala, Professor of Human Cognitive Neuroscience at the University of Edinburgh. Fax: 0131 6513230, e-mail: firstname.lastname@example.org. Cortex is available online at http://www.sciencedirect.com/science/journal/00109452
Elsevier is a world-leading publisher of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including the Lancet (www.thelancet.com) and Cell (www.cell.com), and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include ScienceDirect (www.sciencedirect.com), Scopus (www.scopus.com), Reaxys (www.reaxys.com), MD Consult (www.mdconsult.com) and Nursing Consult (www.nursingconsult.com), which enhance the productivity of science and health professionals, and the SciVal suite (www.scival.com) and MEDai's Pinpoint Review (www.medai.com), which help research and health care institutions deliver better outcomes more cost-effectively.
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