Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that the treatment is a promising alternative for patients whose spinal tumors cannot be surgically removed.
Surgery is the mainstay of treatment for spinal sarcomas; however the tumors are one of the most challenging diseases for orthopedic surgeons. In addition, some patients are not candidates for surgery due to the location of the tumor and/or the patient's condition. In these cases, radiation therapy is generally used. Carbon ion radiotherapy is a type of radiation therapy that is known to be effective for treating various types of inoperable sarcomas, which are tumors that arise from connective tissue. Using carbon ions to target radiation to the tumor, the treatment is minimally invasive, has little effect on adjacent healthy tissues, and has the potential to preserve patients' quality of life.
To investigate the effectiveness and safety of carbon ion radiotherapy for inoperable spinal sarcomas, Reiko Imai, MD, PhD, of the Research Center Hospital for Charged Particle Therapy at the National Institute of Radiological Sciences in Japan, and her colleagues studied the outcomes of 47 patients who received the treatment between 1996 and 2011. In 79 percent of patients, tumor growth was controlled for at least five years. Also, 52 percent of patients survived for at least five years (with 48 percent of patients surviving that long without experiencing cancer progression).
None of the 15 patients with tumors that were smaller than 100 cm3 had a cancer recurrence. No fatal toxicities occurred from the treatment, although one patient had a skin reaction, seven patients experienced vertebral compression salvaged by surgical intervention, and one developed a spinal cord reaction. Twenty-two of the 28 patients who were alive at the last follow-up appointment could walk without supportive devices.
"This report is the first one regarding spinal sarcomas treated with carbon ion radiotherapy, and our findings offer a treatment alternative to patients with inoperable tumors," said Dr. Imai.
Amy Molnar | EurekAlert!
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The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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