A new study reveals that tumors release factors into the bloodstream that inhibit the repair of damaged muscle fibers, and that this contributes to muscle loss during cancer wasting.
Overexpression of the muscle stem cell factor, Pax7, blocks the cells’ ability to differentiate and promotes cancer-induced wasting;
The overexpression of Pax7 promotes cancer wasting by blocking the maturation of muscle cells and their fusion with surrounding fibers, which allows muscle to gain mass;
The overexpression of Pax7 is controlled by NF-kappa B (NF-kB), which has been shown to play multiple roles in cancer. In cachexia, NF-kB causes the deregulation of Pax7 expression, which in turn impairs differentiation of muscle progenitor cells and promotes muscle atrophy;
Because of its tissue specificity, Pax7 inhibition might offer an attractive therapy for cancer cachexia.
614-293-3737, or Darrell.Ward@osumc.edu
Darrell E. Ward | EurekAlert!
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