In the current study, which was performed on mice, the research team led by Professor Klas Kullander at the Department of Neuroscience examined the nerve cells that transfer heat pain. When these nerve cells had lost its capacity to signal, the mice reacted less to heat, as expected, but surprisingly they also started to itch incessantly.
"These findings link together pain from a burn with regulating sensitivity to itching, which was highly surprising and interesting," says Klas Kullander.
Extreme itching is very unpleasant and difficult to treat. For example, it is a common complication following operations and burns. Eczema and other skin disorders can also lead to general itchiness. Greater knowledge of the underlying factors paves the way for developing new forms of treatment for itching, for example, activating pain fibers to reduce itching, which is supported by these findings.
"In the long run, and with the help of more research, we will hopefully be able to fully elucidate what nerve fibers conduct the itching itself, and then we will be able to extinguish the itch at the source," says Klas Kullander.
Reference: Malin C. Lagerström, Katarzyna Rogoz, Bjarke Abrahamsen, Emma Persson,Björn Reinius,Karin Nordenankar,Caroline Ölund,Casey Smith,José Alfredo Mendez,Zhou-Feng Chen,John N. Wood, Åsa Wallén-Mackenzie, Klas Kullander. VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch, Neuron, Volume 68, Issue 3, 529-542.
Klas Kullander | EurekAlert!
Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung
Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
21.08.2017 | Materials Sciences
21.08.2017 | Health and Medicine
21.08.2017 | Materials Sciences