Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Burden of diabetic ketoacidosis still unacceptably high

31.03.2014

CU researcher leads study on why 1 in 3 youth still presenting with DKA

Diabetic ketoacidosis (DKA), a life-threatening but preventable condition, remains an important problem for youth with diabetes and their families. Diabetic ketoacidosis is due to a severe lack of insulin and it is often the presenting symptom of type 1 diabetes. It can also be present at the onset of type 2 diabetes.

SEARCH for Diabetes in Youth, a multi-center, multiethnic study of childhood diabetes, is the largest surveillance effort of diabetes among youth under the age of 20 conducted in the United States to date. The study covers 5 locations across the country where about 5.5 million children live.

In a report in the April, 2014, issue of the Pediatrics, study investigators analyzed data from 5615 youth with type 1 and 1425 youth with type 2 diabetes newly diagnosed between 2002 and 2010. The study, led by Dana Dabelea, MD, PhD, professor and associate dean at the University of Colorado School of Public Health, shows that the frequency of DKA at diagnosis in U.S. youth with type 1 diabetes did not decline over the last 8 years, but remained high compared with other developed countries, with almost a third of all youth with type 1 diabetes presenting in DKA.

Rates were disproportionately high in children younger than 5 years of age, non-White racial/ethnic groups, youth without private health insurance and those with lower family income. Among youth with type 2 diabetes, DKA was much less common and decreased over time, suggesting improved detection or earlier diagnosis of diabetes.

Dabelea says "These data suggest that more needs to be done to begin reducing DKA rates in the future. Previous research suggests that increased community awareness of type 1 diabetes, including parental education and closer monitoring of signs and symptoms of diabetes, may be effective tools. In the U.S., improved health care access especially for underserved populations is also needed to reduce the observed health disparities."

SEARCH has estimated that there were at least 188,811 youth with diabetes in the U.S. in 2009: 168,141 with type 1 diabetes and 19,147 with type 2 diabetes. In the U.S. and worldwide, the incidence of type 1 diabetes in youth has been increasing by 3% to 4% per year, with limited estimates for type 2 diabetes except in minority populations in whom increased prevalence has also been reported.

###

The SEARCH study was funded by the Division of Diabetes Translation at the Centers for Disease Control and Prevention (CDC) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a part of the National Institutes of Health (NIH). It involves five research sites in the states of California (Jean M. Lawrence, ScD, principal investigator for Kaiser Permanente Southern California), Colorado (Dana Dabelea, MD, study co-chair and principal investigator at University of Colorado Denver), Ohio (Lawrence Dolan, MD, principal investigator for Cincinnati Children's Hospital), South Carolina (Elizabeth Mayer-Davis, PhD, study co-chair and principal investigator at University of North Carolina Chapel Hill) and Washington (Catherine Pihoker, MD, principal investigator for Seattle Children's Hospital). The central laboratory for the study is the Northwest Lipid Research Laboratories in Seattle, Washington (Santica Marcovina, PhD, principal investigator). The coordinating center is at the Division of Public Health Sciences at Wake Forest School of Medicine (Ronny Bell, PhD, principal investigator and Ralph B. D`Agostino Jr, co-principal investigator).

About the Colorado School of Public Health

The Colorado School of Public Health is the first and only accredited school of public health in the Rocky Mountain Region, attracting top tier faculty and students from across the country, and providing a vital contribution towards ensuring our region's health and well-being. Collaboratively formed by the University of Colorado Denver, Colorado State University, and the University of Northern Colorado, the Colorado School of Public Health provides training, innovative research and community service to actively address public health issues, including chronic disease, access to health care, environmental threats, emerging infectious diseases, and costly injuries.

Jackie Brinkman | EurekAlert!

Further reports about: Diabetic ketoacidosis Medicine diabetic diagnosis populations

More articles from Studies and Analyses:

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

nachricht Brain connectivity reveals hidden motives
04.03.2016 | Universität Zürich

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Worldwide Success of Tyrolean Wastewater Treatment Technology

A biological and energy-efficient process, developed and patented by the University of Innsbruck, converts nitrogen compounds in wastewater treatment facilities into harmless atmospheric nitrogen gas. This innovative technology is now being refined and marketed jointly with the United States’ DC Water and Sewer Authority (DC Water). The largest DEMON®-system in a wastewater treatment plant is currently being built in Washington, DC.

The DEMON®-system was developed and patented by the University of Innsbruck 11 years ago. Today this successful technology has been implemented in about 70...

Im Focus: Computational high-throughput screening finds hard magnets containing less rare earth elements

Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.

The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...

Im Focus: Atomic precision: technologies for the next-but-one generation of microchips

In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.

In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...

Im Focus: Researchers demonstrate size quantization of Dirac fermions in graphene

Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices

Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.

Im Focus: Graphene: A quantum of current

When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene

In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Networking 4.0: International Laser Technology Congress AKL’16 Shows New Ways of Cooperations

24.05.2016 | Event News

Challenges of rural labor markets

20.05.2016 | Event News

International expert meeting “Health Business Connect” in France

19.05.2016 | Event News

 
Latest News

11 million Euros for research into magnetic field sensors for medical diagnostics

27.05.2016 | Awards Funding

Fungi – a promising source of chemical diversity

27.05.2016 | Life Sciences

New Model of T Cell Activation

27.05.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>