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British study may improve glaucoma assessment and treatment

Results from a recent scientific study in the U.K. may change the way that healthcare professionals measure eye pressure and allow them to assess the risk of glaucoma with greater accuracy. Glaucoma is the second most common cause of irreversible loss of vision worldwide.

The study, published in the Investigative Ophthalmology & Visual Science journal (Intraocular Pressure and Corneal Biomechanics in an Adult British Population -- The EPIC-Norfolk Eye Study), reports the distribution and causes of eye pressure -- medically termed intraocular pressure (IOP).

According to the authors, researchers have long recognized that the clinical methods of assessing eye pressure have suffered from some inaccuracies, specifically as a consequence of the physical properties of the cornea. The EPIC-Norfolk study presents the first large-scale population-based measures of corneal biomechanics.

"Previously, a rather crude measure -- central corneal thickness -- was used as an index of corneal biomechanics," said author Paul J. Foster, MD, PhD, FRCS(Ed), of the University College London Institute of Ophthalmology, "We used a device which generates measures of corneal biomechanics in conjunction with IOP and attempts to 'correct' IOP for corneal physical properties."

Recruited between 1993 and 1997, the EPIC-Norfolk cohort was made up of approximately 25,000 predominantly Caucasian men and women aged 40 to 79 living in eastern England. From 2006 to 2010, a health examination was conducted to objectively assess various physical, cognitive and ocular characteristics of participants. The research team used a non-contact tonometer, the Ocular Response Analyzer, to obtain eye pressure and corneal biomechanical data from 4,184 study participants, now aged 48 to 91 years.

"The accurate measurements of IOP and interpretation of the results in terms of what is seen in the 'normal' population are cardinal pieces of information when healthcare professionals conduct routine eye examinations," said Foster. "We will be using our results to assess the validity of current glaucoma treatment guidelines, with respect to levels of risk attributed to specific levels of IOP."

The ARVO peer-reviewed journal Investigative Ophthalmology & Visual Science (IOVS) publishes results from original hypothesis-based clinical and laboratory research studies, as well as Reviews, Perspectives, and Special Issues. IOVS 2009 Impact Factor ranks No. 4 out of 45 among ophthalmology journals. The journal is online-only and articles are published daily.

The Association for Research in Vision and Ophthalmology (ARVO) is the largest eye and vision research organization in the world. Members include more than 12,500 eye and vision researchers from over 80 countries. ARVO encourages and assists research, training, publication and knowledge-sharing in vision and ophthalmology.

Katrina Norfleet | EurekAlert!
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