The University of Rochester Medical Center study, published online Oct. 12, 2010, by the journal Breast Cancer Research, is good news for women who have a close relative with breast cancer and thus fear that no matter what they do, it won't matter, said lead author Robert E. Gramling, M.D., D.Sc., associate professor of Family Medicine, and Community and Preventive Medicine at URMC.
"It's important to note that a family history of breast cancer can arise in part due to shared unhealthy behaviors that have been passed down for generations," Gramling said. "Untangling the degree to which genes, environments, and behaviors contribute to the disease is difficult. But our study shows that engaging in a healthy lifestyle can help women, even when familial predisposition is involved."
Gramling analyzed data from the Women's Health Initiative Observational Study that began in 1993. The data included women ages 50 to 79, but excluded women with a personal history of breast cancer or with a close relative with early-onset (before age 45) breast cancer.
Researchers decided to exclude women in the latter group because they wanted to focus on whether the American Cancer Society recommendations on diet, exercise and alcohol consumption could plausibly influence disease rates. Women with relatives who were diagnosed prior to age 45 might have a more dominant genetic pattern so they were excluded, the study said.
The WHI-OS data divided women into two groups, those who had a family history of later-onset breast cancer (after age 45) and those who did not. Researchers further categorized the data, based on the degree to which women said they adhered to the ACS guidelines. "Complete adherence" equaled a minimum of 20 minutes of vigorous exercise at least five days a week, maintain a normal weight, and drink no more than one alcoholic beverage a day.
Finally, researchers looked at the cases of invasive breast cancer that arose during a mean follow-up period of 5.4 years. They assessed the relationship between rates of new invasive breast cancer cases, a family history of late-onset breast cancer, and whether either group was modified by the healthy lifestyle recommendations.
Among women with a family history who adhered to all three healthy behaviors, the rate of invasive breast cancer was 5.94 per 1,000 woman-years, compared with 6.97 per 1,000 woman-years among women who adhered to none of the behaviors, the study found.
Among women without a family history who adhered to all three healthy behaviors, the rate of invasive breast cancer was 3.51 per 1,000 woman-years compared to 4.67 per 1,000 woman-years for those who adhered to none.
The amount of risk reduced by adhering to the three health behaviors was the same for women with and without a family history.
Breast cancer is the most common form of cancer diagnosed in women, aside from non-melanoma skin cancer. About 15 percent of all postmenopausal women have a genetic predisposition to the disease.
Given the strong awareness of breast cancer and distress about inheritable risk, Gramling said, it is essential that scientists understand the actions women can take to reduce their risk.
The WHI program is supported by the National Heart, Lung and Blood Institute and the U.S. Department of Health and Human Services.
Leslie Orr | EurekAlert!
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
Urbanization to convert 300,000 km2 of prime croplands
27.12.2016 | Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
17.01.2017 | Earth Sciences
17.01.2017 | Materials Sciences
17.01.2017 | Architecture and Construction