The combined effects of chemotherapy and endocrine therapy may increase the risk of bone fractures in breast cancer survivors.
In a study scheduled for publication in the April issue of the Archives of Physical Medicine and Rehabilitation, researchers from the Oregon Health & Science University Knight Cancer Institute, Portland, asked post-menopausal breast cancer survivors whether they had fallen in the past year and then tracked their falls over a six-month study period. They found evidence that women who have survived breast cancer may fall more often than their peers.
"Our study is the first to consider how breast cancer treatment may increase fall risk by using a comprehensive set of objective measures of fall risk and by exploring mediators of the treatment-falls relationship," commented Kerri M. Winters-Stone, PhD, Associate Professor and Associate Scientist, Oregon Health & Science University, School of Nursing and a member of the Knight Cancer Institute. "Our findings suggest that recently treated postmenopausal breast cancer survivors have higher rates of falling compared with population averages for community-dwelling older adults. Balance disturbances may explain how treatment could have contributed to falls in breast cancer survivors."
Investigators found that 58% of breast cancer survivors had experienced a fall in the previous year and almost half (47%) fell within 6 months after joining the study, a rate nearly double the 25% to 30% annual fall rate reported for community-dwelling older adults over 65 years of age.
Researchers measured a comprehensive set of neuromuscular and balance characteristics known to be associated with falls in 59 study participants. They found that only balance discriminated breast cancer survivors who fell from those who did not. The study findings also suggest that the balance problems may have been related to changes in the vestibular system that were associated with chemotherapy treatment.
Professor Winters-Stone stated, "Falls in breast cancer survivors are understudied and deserve more attention, particularly in light of the increase in fractures after breast cancer treatment and the relationship of falls to fractures. Our findings add to growing evidence that fall risk is increased in breast cancer survivors and that vestibular function may underpin associations between breast cancer treatment and falls."
The article is "Identifying Factors Associated With Falls in Postmenopausal Breast Cancer Survivors: A Multi-Disciplinary Approach" by Kerri M. Winters-Stone, PhD, Britta Torgrimson, PhD, Fay Horak, PhD, PT, Alvin Eisner, PhD, Lillian Nail, PhD, RN, Michael C. Leo, PhD, Steve Chui, MD, and Shiuh-Wen Luoh, MD. It will appear in Archives of Physical Medicine and Rehabilitation, Volume 92, Issue 4 (April 2011), published by Elsevier. doi:10.1016/j.apmr.2010.10.039
Nancy Burns | EurekAlert!
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Process Engineering
23.01.2017 | Physics and Astronomy
23.01.2017 | Life Sciences