For the study, researchers used MRI scans to measure areas of the brain in people with no memory problems or other signs of Alzheimer’s, then followed them for years to see who developed the disease. The researchers specifically focused their measurements on areas known to be involved in AD. Those with smaller brain size in the Alzheimer’s-related areas of the brain were much more likely to develop the disease than those with larger measurements.
“This measure is potentially an important imaging marker of early changes in the brain associated with Alzheimer’s disease that could help predict who might develop the dementia associated with this disease and possibly even how long it would be before dementia develops,” said study author Bradford Dickerson, MD, of Harvard Medical School in Boston and a member of the American Academy of Neurology.
The study involved two separate groups of people with no signs of Alzheimer’s. In the first group, 33 people were followed for an average of 11 years. During that time, eight of the participants developed Alzheimer’s disease dementia. In the second group, 32 people were followed for an average of seven years, and seven of them developed the disease.
The participants were divided into three groups based on the brain scans: those with low, average and high measurements in the Alzheimer’s-related areas. Of the 11 people who had the lowest MRI measurements, 55 percent developed Alzheimer’s, while none of the nine people with the highest measurements developed dementia. Of those with average measurements, 20 percent developed the disease.
“We also found that those who express this MRI marker of the Alzheimer’s disease in the brain were three times more likely to develop dementia over the following 10 years than those with higher measurements,” Dickerson said. “These are preliminary results that are not ready to be applied outside of research studies right now, but we are optimistic that this marker will be useful in the future.”
The study, conducted by investigators at Massachusetts General Hospital/Harvard Medical School in Boston and Rush University in Chicago, was supported by the National Institutes of Health, the Alzheimer’s Association, the Mental Illness and Neuroscience Discovery (MIND) Institute and the Illinois Department of Mental Health.
The American Academy of Neurology, an association of more than 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com.VIDEO: http://www.youtube.com/AANChannel
Rachel L. Seroka | American Academy of Neurology
Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung
Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).
The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
16.08.2017 | Physics and Astronomy
16.08.2017 | Materials Sciences
16.08.2017 | Interdisciplinary Research