Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain Starts Shrinking Nearly a Decade Before Alzheimer’s Appears

15.04.2011
Areas of the brain affected by Alzheimer’s disease may start shrinking up to a decade before dementia is diagnosed, according to a new study published in the April 13, 2011, issue of Neurology®, the medical journal of the American Academy of Neurology.

For the study, researchers used MRI scans to measure areas of the brain in people with no memory problems or other signs of Alzheimer’s, then followed them for years to see who developed the disease. The researchers specifically focused their measurements on areas known to be involved in AD. Those with smaller brain size in the Alzheimer’s-related areas of the brain were much more likely to develop the disease than those with larger measurements.

“This measure is potentially an important imaging marker of early changes in the brain associated with Alzheimer’s disease that could help predict who might develop the dementia associated with this disease and possibly even how long it would be before dementia develops,” said study author Bradford Dickerson, MD, of Harvard Medical School in Boston and a member of the American Academy of Neurology.

The study involved two separate groups of people with no signs of Alzheimer’s. In the first group, 33 people were followed for an average of 11 years. During that time, eight of the participants developed Alzheimer’s disease dementia. In the second group, 32 people were followed for an average of seven years, and seven of them developed the disease.

The participants were divided into three groups based on the brain scans: those with low, average and high measurements in the Alzheimer’s-related areas. Of the 11 people who had the lowest MRI measurements, 55 percent developed Alzheimer’s, while none of the nine people with the highest measurements developed dementia. Of those with average measurements, 20 percent developed the disease.

“We also found that those who express this MRI marker of the Alzheimer’s disease in the brain were three times more likely to develop dementia over the following 10 years than those with higher measurements,” Dickerson said. “These are preliminary results that are not ready to be applied outside of research studies right now, but we are optimistic that this marker will be useful in the future.”

The study, conducted by investigators at Massachusetts General Hospital/Harvard Medical School in Boston and Rush University in Chicago, was supported by the National Institutes of Health, the Alzheimer’s Association, the Mental Illness and Neuroscience Discovery (MIND) Institute and the Illinois Department of Mental Health.

The American Academy of Neurology, an association of more than 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

For more information about the American Academy of Neurology, visit http://www.aan.com.

VIDEO: http://www.youtube.com/AANChannel
TEXT: http://www.aan.com/press
TWEETS: http://www.twitter.com/AANPublic

Rachel L. Seroka | American Academy of Neurology
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

'Lipid asymmetry' plays key role in activating immune cells

20.02.2018 | Life Sciences

MRI technique differentiates benign breast lesions from malignancies

20.02.2018 | Medical Engineering

Major discovery in controlling quantum states of single atoms

20.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>