Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain Starts Shrinking Nearly a Decade Before Alzheimer’s Appears

15.04.2011
Areas of the brain affected by Alzheimer’s disease may start shrinking up to a decade before dementia is diagnosed, according to a new study published in the April 13, 2011, issue of Neurology®, the medical journal of the American Academy of Neurology.

For the study, researchers used MRI scans to measure areas of the brain in people with no memory problems or other signs of Alzheimer’s, then followed them for years to see who developed the disease. The researchers specifically focused their measurements on areas known to be involved in AD. Those with smaller brain size in the Alzheimer’s-related areas of the brain were much more likely to develop the disease than those with larger measurements.

“This measure is potentially an important imaging marker of early changes in the brain associated with Alzheimer’s disease that could help predict who might develop the dementia associated with this disease and possibly even how long it would be before dementia develops,” said study author Bradford Dickerson, MD, of Harvard Medical School in Boston and a member of the American Academy of Neurology.

The study involved two separate groups of people with no signs of Alzheimer’s. In the first group, 33 people were followed for an average of 11 years. During that time, eight of the participants developed Alzheimer’s disease dementia. In the second group, 32 people were followed for an average of seven years, and seven of them developed the disease.

The participants were divided into three groups based on the brain scans: those with low, average and high measurements in the Alzheimer’s-related areas. Of the 11 people who had the lowest MRI measurements, 55 percent developed Alzheimer’s, while none of the nine people with the highest measurements developed dementia. Of those with average measurements, 20 percent developed the disease.

“We also found that those who express this MRI marker of the Alzheimer’s disease in the brain were three times more likely to develop dementia over the following 10 years than those with higher measurements,” Dickerson said. “These are preliminary results that are not ready to be applied outside of research studies right now, but we are optimistic that this marker will be useful in the future.”

The study, conducted by investigators at Massachusetts General Hospital/Harvard Medical School in Boston and Rush University in Chicago, was supported by the National Institutes of Health, the Alzheimer’s Association, the Mental Illness and Neuroscience Discovery (MIND) Institute and the Illinois Department of Mental Health.

The American Academy of Neurology, an association of more than 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

For more information about the American Academy of Neurology, visit http://www.aan.com.

VIDEO: http://www.youtube.com/AANChannel
TEXT: http://www.aan.com/press
TWEETS: http://www.twitter.com/AANPublic

Rachel L. Seroka | American Academy of Neurology
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>