An international group of researchers led by the Peninsula Medical School and the University of Exeter have for the first time identified changes in sex hormones associated with BPA exposure in men, in a large population study. The study results are published in the latest issue of Environmental Health Perspectives.
Researchers analysed data from the InCHIANTI study, an Italian population sample. The team measured the amount of BPA excreted per day in urine samples. 715 adults aged between 20 and 74 years were studied. The study aimed to measure the daily BPA loads excreted by adults, and to examine statistical associations between the amount of BPA exposure and serum oestrogen and testosterone concentrations.
The average BPA daily exposure level in this European study population (over 5 micrograms per day) was slightly higher than recent comparable estimates for the USA population. The study found that higher BPA exposure was statistically associated with endocrine changes in men, specifically small increases in levels of testosterone in the blood.
BPA has a similar molecular structure to oestrogen and does cause some disruption of sex hormone signalling in laboratory animals, but this is the first large human study to suggest that it may have similar effects in adults at 'background' exposure levels.
Professor David Melzer, Professor of Epidemiology and Public Health at the Peninsula Medical School (Exeter, UK), commented: "This is the first big study of BPA from a European country and confirms that 'routine' exposures in the population are not negligible. It also shows that higher exposure to BPA is statistically associated with modest changes in levels of testosterone in men. This finding is consistent with the evidence from laboratory experiments. However, this is just the first step in proving that at 'ordinary' exposure levels, BPA might be active in the human body. This new evidence does justify proper human safety studies to clarify the effects of BPA in people."
BPA is a controversial chemical commonly used in food and drink containers. It has previously caused concerns over health risks to babies, as it is present in some baby's bottles. Several nations have moved to ban BPA from the manufacture of baby's bottles and other feeding equipment. The US Food and Drug administration has committed itself to reducing BPA residues in food. BPA has never undergone formal human safety studies: nearly all the safety experiments have been on laboratory mice or rats, and these may be misleading as BPA is metabolised differently in the human body.
The main source of BPA in people is thought to be from residues in food, leaching out of certain types of polycarbonate and resin packaging. The new study therefore used statistical models adjusted for factors including measures of obesity, to exclude misleading associations in people who consume more food.
BPA has also been associated with thyroid hormone disruption, altered pancreatic beta-cell function, cardiovascular disease and obesity.
BPA is used in polycarbonate plastic products such as refillable drinks containers, some plastic eating utensils and many other products in everyday use. It is one of the world's highest production volume chemicals, with over 2.2 million tonnes (6.4 billion pounds) produced annually. It is detectable in the bodies of more than 90% of the population.
Andrew Gould | EurekAlert!
Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
21.06.2018 | Earth Sciences
21.06.2018 | Life Sciences
21.06.2018 | Earth Sciences