Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone marrow cell transplants to benefit those with heart disease

24.02.2010
Two studies published in the latest issue of Cell Transplantation (18:12) may lead to new treatments for the treatment of heart diseases.

The first study, carried out by a team of Brazilian researchers, found that cell transplantation of bone marrow mononuclear cells (BMMCs) directly into the heart benefited patients suffering from refractory angina.

A separate study carried out by researchers in the Peoples' Republic of China found that apelin, a newly described inotropic peptide, improves heart function following transplantation of BMMCs.

The results of these studies and others are available on-line free of charge at http://www.ingentaconnect.com/content/cog/ct/ .

ReACT ™ bone marrow cell transplants help refractory angina

A team of Brazilian researchers has evaluated the safety and efficacy of a surgical procedure involving multiple injections into the heart (intramyocardial) of a bone marrow mononuclear cells (BMMCs) formulation derived from the patient (autologous) called "Refractory Angina Cell Therapy (ReACT)". The researchers found that the procedure benefitted all eight of the refractory angina patients in the study, all of whom had previously received surgical revascularization.

"The large fraction of monocytes in the ReACT formula appears to be related to the new blood vessel growth, or angiogenesis, that restores perfusion on the myocardial ischemic areas after the cell transplantation," said corresponding author Dr. Nelson Americo Hossne, Jr. of the Paulista School of Medicine, Federal University of Sao Paulo. "For our patients, angina symptom relief began as early as three months post-procedure with continuing improvement through the twelfth month and sustained improvement past 18 months. Symptom relief improved in all patients, suggesting that the effect is sustained, not transitory."

According to Prof. Enio Buffolo, co-author from the same institution, up to 15 percent of patients with coronary artery disease present severe, disabling angina pectoris that cannot be controlled by combinations of current therapies, including drug therapy, coronary angioplasty, or coronary by-pass surgery.

"This results in a substantial decrease in the quality of life for the refractory angina patient," added Prof. Enio Buffolo.

Bone marrow is a natural source of a broad spectrum of cytokines involved in controlling angiogenic and inflammatory processes. Bone marrow white blood cells therefore play an important role in the angiogenic mechanism, contributing to the revascularization of the heart.

The researchers selected the intramyocardial route for injection based on prior experimental data showing higher myocardial stem cell uptake. Endpoints for patient improvement were based on the Canadian Cardiovascular Society Angina Classification (CCSAC) system. According to Dr. Hossne, the ReACT formulation, designed in compliance with Good Manufacturing Practices (GMP) standards criteria, was found to be safe and effective, supporting further study with a larger number of patients.

"Patient improvement by the subjective CCSAC measures was followed by a correlated reduction in the myocardium ischemic area," concluded Dr. Hossne. "This strongly suggests neoangiogenesis as the main mechanism of action for these cells."

Contact: Dr. Nelson Americo Hossne, Jr., Cardiovascular Surgery Division, Surgery Department, Paulista School of Medicine, Federal University of Sao Paulo, Botucato St.
740 Sao Paulo, Brazil ZIP 04023-900.
Tel: +55-11-8166-5050; fax: +55-11-5052-0386,
Email: nelson.hossne@gmail.com
Apelin helps heart function after bone marrow transplant
Apelin, a newly described inotropic peptide (related to the force of heart muscle contraction) with important cardiovascular regulatory properties, contributes to functional improvement in patients with severe heart failure after they have undergone implantation with bone marrow mononuclear cells (BMMC). The study, carried out at the Navy General Hospital in Beijing, evaluated 40 patients with severe heart failure following myocardial infarction. Twenty patients were assigned to receive BMMC transplants and 20 received standard medication. Another 20 healthy patients were assigned as controls.

"Baseline levels of plasma apelin were significantly lower in all heart failure patients as compared to normal, healthy subjects," said corresponding author Dr. Lian Ru Gao. "However, in patients who underwent cell transplantation, apelin increased significantly from three to 21 days post-transplantation. This increase in apelin was also followed by significant improvement in cardiac function."

In patients who received standard treatment, there was no increase in apelin.

According to the researchers, apelin, known to be a potent inotropic agent, was recently recognized as an important regulator of myocardial cell specification and heart development. In addition, reports that apelin concentration decreased with heart function impairment led the researchers to hypothesize that bone marrow transplantation might play a role in improving heart function by releasing apelin.

"Our objective was to assess how apelin plasma levels changed post-transplantation as well as to determine the relationship between increased apelin levels and heart function," added Dr. Gao.

Apelin levels increased in all patients who received BMMCs, and cardiac function improved as reflected by the relief of dyspnea and other measures, and so the researchers concluded that apelin signaling may play an important role in the heart function improvement observed after BMMC transplantation.

"Increased apelin levels may act as a paracrine mediator produced from BMMCs and may play an important role in the treatment of heart failure through autocrine and paracrine mechanisms," Dr. Gao concluded.

"Both studies demonstrate a possible mechanistic approach in a clinical trial either via the role of monocytes or Apelin to improve cardiac function" said Dr. Amit Patel associate professor of surgery at the University of Utah School of Medicine and the cardiovascular, skin, other tissue section editor of Cell Transplantation ."These important findings further enhance the understanding of the use of bone marrow derived cell therapy for the treatment of cardiovascular disease.".

Contact: Dr. Lian Ru Gao, Department of Cardiology, Navy General Hospital, 6 Fucheng Road, Beijing 100037, China.
Tel: 011-86-10-88180197; fax: 011-86-10-68780127043,
Email: lianru@yahoo.com.cn
The editorial offices for Cell Transplantation are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. Contact, David Eve, PhD. at celltransplantation@gmail.com or Camillo Ricordi, MD at ricordi@miami.edu

News Release by Randolph Fillmore, Florida Science Communications.

David Eve | EurekAlert!
Further information:
http://www.ingentaconnect.com/content/cog/ct/

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>