Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Berkeley study shows ozone and nicotine a bad combination for asthma

Another reason for including asthma on the list of potential health risks posed by secondhand tobacco smoke, especially for non-smokers, has been uncovered. Furthermore, the practice of using ozone to remove the smell of tobacco smoke from indoor environments, including hotel rooms and the interiors of vehicles, is probably a bad idea.

A new study by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) shows that ozone can react with the nicotine in secondhand smoke to form ultrafine particles that may become a bigger threat to asthma sufferers than nicotine itself. These ultrafine particles also become major components of thirdhand smoke – the residue from tobacco smoke that persists long after a cigarette or cigar has been extinguished.

“Our study reveals that nicotine can react with ozone to form secondary organic aerosols that are less than 100 nanometers in diameter and become a source of thirdhand smoke,” says Mohamad Sleiman, a chemist with the Indoor Environment Department of Berkeley Lab’s Environmental Energy Technologies Division (EETD) who led this research.

“Because of their size and high surface area to volume ratio, ultrafine particles have the capacity to carry and deposit potentially harmful organic chemicals deep into the lower respiratory tract where they promote oxidative stress,” Sleiman says. “It’s been well established by others that the elderly and the very young are at greatest risk.”

Results of this study have been reported in the journal Atmospheric Environment in a paper titled “Secondary organic aerosol formation from ozone-initiated reactions with nicotine and secondhand tobacco smoke.” Co-authoring this paper with Sleiman were Hugo Destaillats and Lara Gundel, also with EETD’s Indoor Environment Department, and Jared Smith, Chen-Lin Liu, Musahid Ahmed and Kevin Wilson with the Chemical Dynamics Group of Berkeley Lab’s Chemical Sciences Division. The study was carried out under a grant from the University of California’s Tobacco-Related Disease Research Program.

The dangers of mainstream and secondhand tobacco smoke, which contain several thousand chemical toxins distributed as particles or gases, have been well documented. This past February, a study, also spearheaded by Sleiman, Destaillats and Gundel, revealed the potential health hazards posed by thirdhand tobacco smoke which was shown to react with nitrous acid, a common indoor air pollutant, to produce dangerous carcinogens. Until now, however, in terms of forming ultrafine particles, there have been no studies on the reaction of nicotine with ozone.

Released as a vapor by the burning of tobacco, nicotine is a strong and persistent adsorbent onto indoor surfaces that is released back to indoor air for a period of months after smoking ceased. Ozone is a common urban pollutant that infiltrates from outdoor air through ventilation that has been linked to health problems, including asthma and respiratory ailments.

Says co-author Gundel, “Not only did we find that nicotine from secondhand smoke reacts with ozone to make ultrafine particles – a new and stunning development – but we also found that several oxidized products of ozone and nicotine have higher values on the asthma hazard index than nicotine itself.”

Says co-author Destaillats, “In our previous study, we found that carcinogens were formed on indoor surfaces, which can lead to exposures that are likely to be dominated by dermal uptake and dust ingestion. This study suggests a different exposure pathway to aged secondhand or thirdhand smoke through the formation and inhalation of ultrafine particles. Also, our group had previously described the formation of secondary organic aerosols in reaction of indoor ozone with terpenoids, commonly present in household products. But this is the first time that nicotine has been tagged as a potential candidate to form ultrafine particles or aerosols through a reaction with ozone.”

To identify the products formed when nicotine in secondhand smoke is reacted with ozone, Sleiman and his co-authors utilized the unique capabilities of Berkeley Lab’s Advanced Light Source (ALS), a premier source of x-ray and ultraviolet light for scientific research. Working at ALS Beamline 9.0., which is optimized for the study of chemical dynamics using vacuum ultraviolet (VUV) light and features an aerosol chemistry experimental station, the researchers found new chemical compounds forming within one hour after the start of the reaction.

“The tunable VUV light of Beamline 9.0.2’s custom-built VUV aerosol mass spectrometer minimized the fragmentation of organic molecules and enabled us to chemically characterize the secondhand smoke and identify individual constituents of secondary organic aerosols,” says Sleiman. “The identification of multifunctional compounds, such as carbonyls and amines, present in the ultrafine particles, made it possible for us to estimate the Asthma Hazard Index for these compounds.”

While the findings in this study support recommendations from the California EPA and the Air Resources Board that discourage the use of ozone-generating “air purifiers,” which among other applications, have been used for the removal of tobacco odors, the Berkeley Lab researchers caution that the levels of both ozone and nicotine in their study were at the high end of typical indoor conditions.

Says Sleiman, “In addition, we need to do further investigations to verify that the formation of ultrafine particles occurs under a range of real world conditions. However, given the high levels of nicotine measured indoors when smoking takes place regularly and the significant yield of ultrafine particles formation in our study, our findings suggest new link between asthma and exposure to secondhand and thirdhand smoke.”

Berkeley Lab is a U.S. Department of Energy national laboratory located in Berkeley, California. It conducts unclassified scientific research for DOE’s Office of Science and is managed by the University of California. Visit our Website at

Additional Information

For more information about Berkeley Lab’s Indoor Environment Department and its researchers visit the Website at

For more information about the Chemical Dynamics Beamline at the Advanced Light Source visit the Website at

For more information about the Advanced Light Source visit the Website at

For more information on the University of California’s Tobacco-Related Disease Research Program (TRDRP) visit the Website at or contact Kamlesh Asotra at or 510-287-3366.

Lynn Yarris | EurekAlert!
Further information:

More articles from Studies and Analyses:

nachricht Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel light sources made of 2D materials

Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.

So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Prototype device for measuring graphene-based electromagnetic radiation created

28.10.2016 | Power and Electrical Engineering

Gamma ray camera offers new view on ultra-high energy electrons in plasma

28.10.2016 | Physics and Astronomy

When fat cells change their colour

28.10.2016 | Life Sciences

More VideoLinks >>>