Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bath researchers study how cancer cells come unstuck

22.08.2008
Scientists in the Department of Biology & Biochemistry at the University of Bath have started a three year study into the junctions that hold cells together, giving insight into how cancer cells can break off and spread to other parts of the body.

Cancer affects one in three people at some point in their lives, with most cancer deaths being caused by the development of secondary tumours in other parts of the body. This research, funded by leading medical charity Cancer Research UK, could help scientists better understand what causes cancer to spread and may suggest new ways it could be treated in the future.

Normal cells are held together by junctions on the cell surface, but in some cancers these junctions are lost. This makes the cancerous cells more likely to break off and spread tumours to other parts of the body. Dr Andrew Chalmers and Dr Paul Whitley, both lecturers from the Department of Biology & Biochemistry, are studying how a group of proteins called ESCRTs are involved in the loss of these junctions in kidney and intestine cells.

“ESCRTs are like the recycling units of the cell; they oversee the constant intake, break down and replenishing of junctions on the cell surface,” explained Dr Chalmers.

“In a cancer cell where ESCRTs are damaged, the junctions may not be restored properly; this can cause cells to separate and migrate to form secondary tumours in other parts of the body.

“Previous studies have shown a link between ESCRTs and the loss of junctions in cells of fruit flies, so we want to see whether this is also true in humans.”

During this three year project, the researchers plan to block ESCRTs in cells grown in the lab to see the effects on the junctions. They will also be looking at whether mutations of ESCRTs are more common in certain types of cancer.

Dr Paul Whitley added: “This work should tell us more about the role of ESCRTs in cancer and provide possible new targets for therapy in the future.”

Vicky Just | alfa
Further information:
http://www.bath.ac.uk
http://www.bath.ac.uk/bio-sci/about/index.html

Further reports about: Biochemistry Biology Cancer ESCRTs cancer cells intestine cells secondary tumours

More articles from Studies and Analyses:

nachricht Physics of bubbles could explain language patterns
25.07.2017 | University of Portsmouth

nachricht Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA mission surfs through waves in space to understand space weather

25.07.2017 | Physics and Astronomy

Strength of tectonic plates may explain shape of the Tibetan Plateau, study finds

25.07.2017 | Earth Sciences

The dense vessel network regulates formation of thrombocytes in the bone marrow

25.07.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>