Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

“Antedrugs”: A Safer Approach To Drug Therapy

21.04.2009
One lab’s groundbreaking approach to tailoring drugs that meet only a specific target within the body has focused on anti-inflammatory, anti-AIDS and anti-cancer drugs since 1982

Corticosteroids are powerful drugs used to treat inflammatory conditions such as asthma and other chronic diseases which has made them among the most widely prescribed drugs.

Although the anti-inflammatory drugs offer swift relief to the patient, they can carry with them serious side effects. For example, the inflammatory steroids used to treat a child’s asthma, but can stunt the child’s growth over time. Similarly, adult treatment of Addison’s disease, which President John F. Kennedy endured, can lead to the development of diabetes and hypertension.

For more than 20 years, one research team has been working to develop a safer approach that would eliminate inflammation without causing damage to the body. Such drugs, called “antedrugs” have been developed in a lab at Florida A&M’s College of Pharmacy. The efforts have been spearheaded by Dr. Henry J. Lee who has led antedrug research in anti-inflammatory, anti-AIDS and anti-cancer drugs for nearly 30 years.

A New Study

Lee and his team have recently completed a new study entitled, Anti-Inflammatory Activities of New Steroidal Antedrugs Isoxazoline Derivatives. It was conducted by Drs. Henry J. Lee, Younes J. Errahali, LeeShawn D. Thomas, Brenda G. Arnold and Glory B. Brown, all of the Florida Agricultural and Mechanical University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, Florida. The researchers will discuss their work at the 122nd Annual Meeting of the American Physiological Society (APS; www.the-APS.org/press) which is part of the Experimental Biology 2009 scientific conference. The meeting will be held April 18-22, 2009 in New Orleans.

The Study

Antedrug design is a new approach to create safer drugs that attack a problem such as inflammation then quickly become inactive before they can cause damage. The primary objective of this study was to synthesize a new group of corticosteroids that have anti-asthmatic and anti-inflammatory properties without adverse side effects.

The researchers synthesized new antedrugs, isoxazoline derivatives, from prednisolone. They then tested the derivatives in a test tube and found that antedrugs effectively reduced inflammation. In fact, they found isoxazoline derivatives were five times more potent than prednisolone in binding affinities to the cell corticosteroids receptors and reducing inflammation.

The researchers also studied the isoxazoline derivatives in the lung and liver cells of rats and found that the antedrugs significantly reduced the cell inflammation. In addition, the rat plasma began metabolizing rapidly the antedrugs to an inactive form with the half lives less than five minutes and more than 95% of prednisolone remained unchanged even after 100 min incubation.

Results

These results suggest that isoxazoline derivatives compared to conventional steroids improve topical anti-inflammatory activity without causing systemic damage. “This is a very promising outcome,” according to Dr. Lee. Additional studies are currently underway, using a new group of corticosteroids in the treatment of asthma exacerbation and chronic pulmonary inflammation without systemic side effects such as body weight and hypothalamic-pituitary-adrenal axis change.

This project research described was supported by the National Institutes of Health, 5S06GM008111-36 NIGMS/MBRS and 2G12RR03020-24 / NCRR/RCMI. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCRR, NIGMS or the NIH.

Physiology is the study of how molecules, cells, tissues and organs function to create health or disease. The American Physiological Society (APS; www.The-APS.org/press) has been an integral part of this discovery process since it was established in 1887.

Donna Krupa | EurekAlert!
Further information:
http://www.the-aps.org

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>