New animal research has identified factors, such as the stress response and immune system, that may play important roles in depression. Scientists have also found that the regulation of nerve cell signals influences depression in animals, and that new drug combinations may more effectively treat it.
The findings were presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news on brain science and health.
Depression is a common mental disorder that affects more than 121 million people worldwide, according to the World Health Organization. Studies show the most effective treatment for moderate or severe depression is a combination of antidepressant medication and psychotherapy. However, 20 to 40 percent of people with depression are not helped by existing therapies, highlighting the need for new treatment targets and approaches.
Today's new findings show that:
An inability to cope with stress may play a role in depression. When placed in stressful situations, zebrafish with a mutation in a receptor important in stress management displayed depression-like behavior, which was reversed when the fish were given Prozac (Herwig Baier, PhD, abstract 884.1, see attached summary).
The immune system may be a factor in depression. When an immune hormone that carries "sickness" signals to the brain was blocked in mice, the animals showed fewer depression symptoms (Simon Sydserff, PhD, abstract 666.24, see attached summary).
Mice that lack a molecule involved in regulating nerve cell signals are more active and resilient to stressful situations, behaving the same way as animals given antidepressant drugs. The discovery offers a new target for controlling brain chemicals involved in mood regulation (James Bibb, PhD, abstract 741.9, see attached summary).
Two antidepressants may be better than one. A new animal study shows that when drugs that alter two mood-regulating brain chemicals are combined, they produce a greater antidepressant response (Marina Picciotto, PhD, abstract 769.9, see attached summary).
Other recent findings discussed show that:
Two brain molecules, p11 and brain-derived neurotrophic factor, are key to making antidepressants work. In time, these results might lead to the development of faster-acting antidepressants with fewer side effects (Jennifer Warner-Schmidt, PhD, see attached speaker's summary).
"Finding treatments for disorders of the nervous system is a social imperative," said press conference moderator Robert Greene, MD, PhD, of the University of Texas Southwestern Medical School, an expert in psychiatric disorders. "Basic neuroscience research has formed the basis for significant progress in discovering potentially powerful strategies for new, more effective therapies to combat depression."
This research was supported by national funding agencies, such as the National Institutes of Health, as well as private and philanthropic organizations.
Kat Snodgrass | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy