“Those who are 85 and older make up the fastest growing population in the world,” said study author Mark Bondi, PhD, with the University of California San Diego School of Medicine and VA San Diego Healthcare System. “Our study shows how age has a dramatic effect on the profile of brain atrophy and cognitive changes evident in Alzheimer’s disease.”
The study involved 105 people with Alzheimer’s disease and 125 people who were free of dementia and recruited through the Alzheimer’s Disease Neuroimaging Initiative. Participants were grouped into those who were between the ages of 60 and 75 and those age 80 years and older. All were given tests that measured language, attention and speed of processing information, executive function, and immediate and delayed ability to recall information.
Participants also underwent brain scans to measure the thickness of the outermost tissue layers in the cerebrum of the brain.
Even though the two groups had similar levels of overall cognitive impairment, researchers found that the pattern of changes associated with Alzheimer’s disease appeared to be less noticeable in people over the age of 80 (very-old) compared to those between the ages of 69 and 75 (young-old). When compared to their healthy counterparts, executive function, immediate memory and attention/processing speed were less abnormal in those considered very old compared to those considered young-old. The very-old also showed less severe thinning of portions of cerebral cortex and the overall cerebrum than the young-old, as compared to their healthy counterparts. This is in part because these brain areas decrease in thickness due to age, so there are fewer differences between the healthy very-old brain and the very-old brain with Alzheimer’s disease, Bondi said.
The study was supported by National Institute on Aging, the National Institutes of Health, the National Institute of Biomedical Imaging and Bioengineering, Abbott, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson and Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc., F. Hoffman-La Roche, Schering-Plough, Synarc, Inc., Wyeth, the Alzheimer's Association and Alzheimer's Drug Discovery Foundation with participation from the U.S. Food and Drug Administration, the Northern California Institute for Research and Education and the Dana Foundation.
The American Academy of Neurology, an association of more than 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com.
Leah C. Reilly | American Academy of Neurology
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences