However, a randomized clinic trial conducted by the American Lung Association's Asthma Clinical Group found that the addition of lansoprazole does not improve asthma symptoms or the control of asthma in children and may increase the risk for upper respiratory infections and other adverse events. Results of the study appear in the January 25 issue of JAMA.
Lansoprazole belongs to a class of drugs called proton pump inhibitors (PPIs) that reduce acid in the stomach. Use of these drugs, including for the treatment of asthma symptoms, has risen dramatically in children over the last decade.
"The data were very clear. Lansoprazole did not improve asthma symptoms in children as compared to a placebo, and there is no evidence to support prescribing these drugs to treat asthma in children," said Janet Holbrook, PhD, corresponding author of the study and associate professor in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. "In our study, children taking lansoprazole showed an increased risk for respiratory infection, sore throats and bronchitis." The Bloomberg School's Center for Clinical Trials served as data coordinating center for the research team.
For the study, researchers from 18 trial sites studied 306 children ages 6 to 17 years. All study participants had inadequately controlled asthma despite taking inhaled corticosteroids but did not have the typical symptoms of GER. Approximately 40 percent of participants were identified as having GER based on diagnostic testing. The participants were randomly selected to receive either a daily dose of lansoprazole or a placebo pill over a 24-week period in addition to their inhaled steroid therapy.
The researchers found no significant differences in severity of asthma symptoms or overall lung function between the group taking lansoprazole and the group receiving the placebo, including in the children positively identified as having GER. An earlier separate study of adults conducted by the same research team showed similar results.
The study was funded by the National Heart, Lung, and Blood Institute (NHLBI), which is part of the National Institutes of Health.
Tim Parsons | EurekAlert!
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Health and Medicine
07.12.2016 | Life Sciences
07.12.2016 | Health and Medicine