There are many reports assessing the psychological damage resulting from childhood abuse, and the effects on physical health have also been well documented. For instance, this "toxic" stress has been linked to elevated cholesterol, cardiovascular disease, metabolic syndrome and other physical conditions posing a significant health risk. The research into the physical effects of abuse, however, has focused on separate, individual systems.
A new UCLA-led study for the first time examines the effects of abuse and lack of parental affection across the body's entire regulatory system, and finds a strong biological link for how negative early life experiences affect physical health. The study is published online by the Proceedings of the National Academy of Sciences.
"Our findings suggest that there may be a way to reduce the impact abuse has, at least in terms of physical health," said Judith E. Carroll, a research scientist at the Cousins Center for Psychoneuroimmunology at UCLA, and the study's lead author. "If the child has love from parental figures they may be more protected from the impact of abuse on adult biological risk for health problems than those who don't have that loving adult in their life."
The researchers studied 756 adults who had participated in a study called Coronary Artery Risk Development in Young Adults (CARDIA). They measured 18 biological markers of health risk, such as blood pressure, heart rate, stress hormone, cholesterol, waist circumference, inflammation, and blood sugar regulation, and added up their risks across these markers to create a summary index called "allostatic load." Values at the upper range across these markers indicated they were at higher biological risk for disease. Previous research has shown that higher levels of allostatic load are associated with increased likelihood of a negative health event such as a heart attack or stroke, or show declines in physical or cognitive functioning.
To determine the study subjects' childhood stress the researchers used a well-validated self-report scale called the Risky Families Questionnaire.
They found a significant link between reports of childhood abuse and multisystem health risks But those who reported higher amounts of parental warmth and affection in their childhood had lower multisystem health risks The researchers also found a significant interaction of abuse and warmth, so that individuals reporting low levels of love and affection and high levels of abuse in childhood had the highest multisystem risk in adulthood.
The researchers suggest that toxic childhood stress alters neural responses to stress, boosting the emotional and physical arousal to threat and making it more difficult for that reaction to be shut off.
"Our findings highlight the extent to which these early childhood experiences are associated with evidence of increased biological risks across nearly all of the body's major regulatory systems" said Teresa Seeman, professor of medicine in the division of geriatrics at the David Geffen School of Medicine and of epidemiology at the Fielding School of Public Health at UCLA, and the paper's senior author. "If we only look at individual biological parameters such as blood pressure or cholesterol, we would miss the fact that the early childhood experiences are related to a much broader set of biological risk indicators – suggesting the range of health risks that may result from such adverse childhood exposures".
The authors note that the findings are based on a cross-sectional analysis and do not prove causation. It used information provided by the participants, so there may be some recall bias. Also, the analysis may not have captured other factors affecting regulatory systems, such as poor nutrition or environmental pollution.
But the findings suggest that parental warmth and affection protect one against the harmful effects of toxic childhood stress. Also, the lingering effects of childhood abuse can be linked to age-related diseases such as cardiovascular disease. Among other things, this could have an effect on long-term health care costs.
"It is our hope that this will encourage public policy support for early interventions," Carroll said. "If we intervene early in risky families and at places that provide care for children by educating and training parents, teachers, and other caregivers in how to provide a loving and nurturing environment, we may also improve the long term health trajectories of those kids."
Additional study co-authors are Shelley E. Taylor of UCLA, Tara L. Gruenewald of the University of Southern California, Denise Janicki-Deverts of Carnegie Mellon University, and Karen A. Matthews of the University of Pittsburgh.
The CARDIA study is conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with the University of Alabama at Birmingham (Grants N01-HC95095 and N01-HC48047); University of Minnesota (Grant N01-HC48048); Northwestern University (Grant N01-HC48049); Kaiser Foundation Research Institute (Grant N01-HC48050); University of California, Irvine; Echocardiography Reading Center (Grant N01-HC-45134); Harbor–University of California (Los Angeles, CA) Research Education Institute and Computed Tomography Reading Center (Grant N01-HC-05187). This study was also supported by MacArthur Research Network on Socioeconomic Status and Health through grants from the John D. and Catherine T. MacArthur Foundation; and by Grant T32-MH19925 and the Cousins Center for Psychoneuroimmunology at the UCLA.
The Cousins Center for Psychoneuroimmunology encompasses an interdisciplinary network of scientists working to advance the understanding of psychoneuroimmunology by linking basic and clinical research programs and by translating findings into clinical practice. The center is affiliated with the Semel Institute for Neuroscience and Human Behavior and the David Geffen School of Medicine at UCLA.
The UCLA Division of Geriatrics, within the Department of Medicine at the David Geffen School of Medicine at UCLA, offers comprehensive outpatient and inpatient services at several convenient locations, and works closely with other UCLA programs that strive to improve or maintain the quality of life of seniors. UCLA geriatricians are specialists in the managing of the overall health of people age 65 and older and treating the medical disorders that frequently affect the elderly, including falls and immobility, urinary incontinence (lack of bladder control), memory loss and dementia, arthritis, high blood pressure, heart disease, osteoporosis and diabetes. As a result of their specialized training, geriatricians can knowledgably consider and address a broad spectrum of health-related factors – including medical, psychological and social – when treating their patients.
Enrique Rivero | EurekAlert!
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
23.03.2017 | Life Sciences
23.03.2017 | Power and Electrical Engineering
23.03.2017 | Earth Sciences