The researchers found that women considered "underweight" or "obese," or who had increased abdominal obesity prior to cancer diagnosis seemed to face a greater risk of mortality.
"Maintaining a healthy body weight is beneficial for postmenopausal women. This may also be beneficial for those diagnosed with colon cancer later in life. It looks like abdominal obesity may be a useful indicator of higher colon cancer mortality," said Anna E. Prizment, Ph.D., M.P.H., a postdoctoral fellow in the division of epidemiology and community health at the University of Minnesota, Masonic Cancer Center. "It is too early to say whether a decrease in weight characteristics after diagnosis will also decrease mortality risk; at that point it may be too late. Therefore, it's best to maintain a normal, healthy body weight throughout life."
Prizment and colleagues extracted data from the Iowa Women's Health Study, which included 1,096 women diagnosed with colon cancer who were observed over a maximum 20-year period. During that time, 493 died, of which 289 died from colon cancer.
Women classified as obese, with a BMI of at least 30 kg/m2, had a 45 percent increased overall mortality rate. The few women classified as underweight, with a BMI less than 18.5 kg/m2, had an 89 percent increased mortality rate compared to those with normal BMI.
Furthermore, women with high waist-to-hip ratio had a 30 to 40 percent greater risk of colon cancer related death. Prizment said that the "exact mechanisms underlying the link between obesity and higher mortality of colon cancer patients are unknown."
"Obese people may be diagnosed at later stage, have different treatment or more comorbidities," she said. However, the facts that the increased abdominal obesity was associated with colon cancer mortality and those associations persisted after correcting for age, stage at cancer diagnosis and comorbidities suggest that obesity could have a direct biological effect. Obese women, especially those with higher abdominal obesity, have higher hormone levels and may have more aggressive cancer. These women have been already known to have a higher risk of developing colon cancer.
Prizment encouraged further investigation of the potential effect of obesity, in particular, abdominal obesity, on the prognosis after colon cancer diagnosis.
Subscribe to the Cancer Epidemiology, Biomarkers & Prevention RSS Feed: http://cebp.aacrjournals.org/rss/recent.xml
Subscribe to the AACR RSS News Feed: http://feeds.feedburner.com/aacr
The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, the AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes 32,000 basic, translational and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 90 other countries. The AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants, research fellowships and career development awards. The AACR Annual Meeting attracts more than 18,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment and patient care. The AACR publishes six major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; and Cancer Prevention Research. The AACR also publishes CR, a magazine for cancer survivors and their families, patient advocates, physicians and scientists, providing a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship and advocacy.
Jeremy Moore | EurekAlert!
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences