“We already know that women with PCOS often have insulin resistance, in other words the body’s cells are less sensitive to insulin, and are at greater risk of developing type 2 diabetes,” says Louise Mannerås-Holm, a researcher at the Department of Physiology at the Sahlgrenska Academy’s Institute of Neuroscience and Physiology. “High levels of testosterone in the blood of these women are thought to be one of the main reasons for this.”
But the current study, published in The Journal of Clinical Endocrinology and Metabolism, shows that aberrations in adipose tissue could be more significant in this respect. Around half of all women with PCOS are overweight or obese and it is widely believed that the excess fat is stored mainly around the middle. The study therefore pair-matched 31 women with PCOS and 31 women without the syndrome, but of the same age and BMI. Ages ranged from 21 to 37, and BMI from underweight to extremely obese. “The comparison between the groups shows that women with PCOS do not have an abnormally large amount of fat around the middle, but that they do have large fat cells and altered adipose tissue function,” says Mannerås-Holm.In women with PCOS, adipose tissue produces less of the “good” hormone adiponectin which increases the body’s sensitivity to insulin. Furthermore, activity of the enzyme lipoprotein lipase is low, which can affect the metabolism of fat in the body. A total of 74 women with PCOS took part in the study, which also shows that the aberrations in adipose tissue in PCOS could play a key role in increasing these women’s risk of developing type 2 diabetes. The factors linked most strongly with insulin resistance were the size of the fat cells, the quantity of adiponectin in the blood and waist size. However,
testosterone levels did not play a significant role in this analysis.
“We don’t entirely understand the mechanism behind the large fat cells’ unfavourable effects, but the results show that it is particularly important for the health of women with PCOS that they don’t put on weight,” says Mannerås-Holm.POLYCYSTIC OVARY SYNDROME (PCOS)
health led by docent Elisabet Stener-Victorin at the Sahlgrenska Academy.For more information, please contact:
Authors: Louise Mannerås-Holm, Henrik Leonhardt, Joel Kullberg, Eva Jennische, Anders Odén, Göran Holm, Mikael Hellström, Lars Lönn, Gunilla Olivecrona, Elisabet Stener-Victorin and Malin Lönn.
Helena Aaberg | idw
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences