Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aberrations in adipose tissue could increase risk of diabetes in PCOS

17.01.2011
A study from the University of Gothenburg, shows that women with polycystic ovary syndrome (PCOS) have aberrations in their adipose (fat) tissue. This discovery could provide answers as to why these women develop type 2 diabetes more readily, and shows that it is important for their health that women with PCOS do not put on weight.

“We already know that women with PCOS often have insulin resistance, in other words the body’s cells are less sensitive to insulin, and are at greater risk of developing type 2 diabetes,” says Louise Mannerås-Holm, a researcher at the Department of Physiology at the Sahlgrenska Academy’s Institute of Neuroscience and Physiology. “High levels of testosterone in the blood of these women are thought to be one of the main reasons for this.”

But the current study, published in The Journal of Clinical Endocrinology and Metabolism, shows that aberrations in adipose tissue could be more significant in this respect. Around half of all women with PCOS are overweight or obese and it is widely believed that the excess fat is stored mainly around the middle. The study therefore pair-matched 31 women with PCOS and 31 women without the syndrome, but of the same age and BMI. Ages ranged from 21 to 37, and BMI from underweight to extremely obese. “The comparison between the groups shows that women with PCOS do not have an abnormally large amount of fat around the middle, but that they do have large fat cells and altered adipose tissue function,” says Mannerås-Holm.

In women with PCOS, adipose tissue produces less of the “good” hormone adiponectin which increases the body’s sensitivity to insulin. Furthermore, activity of the enzyme lipoprotein lipase is low, which can affect the metabolism of fat in the body. A total of 74 women with PCOS took part in the study, which also shows that the aberrations in adipose tissue in PCOS could play a key role in increasing these women’s risk of developing type 2 diabetes. The factors linked most strongly with insulin resistance were the size of the fat cells, the quantity of adiponectin in the blood and waist size. However,

testosterone levels did not play a significant role in this analysis.

“We don’t entirely understand the mechanism behind the large fat cells’ unfavourable effects, but the results show that it is particularly important for the health of women with PCOS that they don’t put on weight,” says Mannerås-Holm.

POLYCYSTIC OVARY SYNDROME (PCOS)
PCOS is the most common hormonal disorder in women of fertile age. Characterised by insulin resistance and high levels of testosterone, PCOS affects 5-10% of fertile women. The most common symptoms are irregular or disrupted menstruation, problem hair growth, acne and excess weight. In the long term women with PCOS are at greater risk of developing type 2 diabetes, and probably cardiovascular disease too. Extensive research is under way to increase our knowledge of the underlying factors. Docent Malin Lönn at the Sahlgrenska Academy supervised the study of adipose tissue in PCOS, which was part of an extensive investigation into these women’s physical and mental

health led by docent Elisabet Stener-Victorin at the Sahlgrenska Academy.

For more information, please contact:
Louise Mannerås-Holm, researcher at the Department of Physiology, Institute of
Neuroscience and Physiology, Sahlgrenska Academy,
telephone +46(0)31 7863 536,
e-mail louise.manneras@neuro.gu.se
Journal: The Journal of Clinical Endocrinology and Metabolism
Title of the article: Adipose tissue has aberrant morphology and function in PCOS – enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance

Authors: Louise Mannerås-Holm, Henrik Leonhardt, Joel Kullberg, Eva Jennische, Anders Odén, Göran Holm, Mikael Hellström, Lars Lönn, Gunilla Olivecrona, Elisabet Stener-Victorin and Malin Lönn.

Helena Aaberg | idw
Further information:
http://www.gu.se/

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>