The study investigated the effect of dietary fat (classified as total, saturated, monounsaturated, polyunsaturated, omega 6, omega 3 and trans) on a range of preclinical and clinical outcomes in women having IVF. Results showed that the intake of saturated fat was inversely related to the number of mature oocytes retrieved, while polyunsaturated fat consumption was inversely associated with early embryo quality.(1)
Dietary fat intake has been previously studied for its effect on reproductive health; for example, a high intake of trans-fats has been associated with ovulatory infertility (as in polycystic ovary syndrome) and miscarriage, while saturated fats have been related to lower sperm concentrations. But so far little has been known about the effect of dietary fat intake on the outcome of fertility treatment.
The results of this study were presented today at the annual meeting of ESHRE (European Society of Human Reproduction and Embryology) by Dr Jorge Chavarro, Assistant Professor of Nutrition and Epidemiology at Harvard School of Public Health, USA.
The study took place among 147 women having IVF at the Massachusetts General Hospital Fertility Center. Preclinical assessments included oocyte development, fertilisation, embryo quality and cleavage rate, while clinical outcomes (pregnancy, live birth) were recorded in all women who had embryo transfer. The women were also categorised into tertiles of fat intake, with outcomes compared in relation to the lowest tertile. Results were controlled for other sources of energy, infertility diagnosis, ovarian stimulation protocol, body mass index (BMI) and smoking status.
Following statistical analysis it was found that women with higher intakes of total fat had fewer metaphase II (MII) oocytes retrieved than women in the lowest tertile. This association was driven by intake of saturated fat, said Professor Chavarro. Women in the highest tertile of saturated fat intake had on average 9.3 MII oocytes, while those with the lowest intake had 11.6 MII oocytes.
"Only MII oocytes can be used for IVF," he explained. "Thus, having fewer mature oocytes can mean fewer embryos to choose from for fresh transfer or future transfer following cryopreservation, particularly among women who respond poorly to ovarian stimulation."
Polyunsaturated fat consumption was found inversely related to embryo quality. Women in the highest tertile of polyunsaturated fat intake had a higher proportion of poor quality embryos and more slowly cleaving embryos than had women in the lowest tertile of intake.
Fat consumption was also associated with clinical outcomes. Higher intakes of monounsaturated fat were related to higher odds of live birth. The odds of a live birth after embryo transfer in women with the highest intake of monounsaturated fat were 3.45 times higher than those of women with the lowest intake.
"We were not entirely surprised that different types of fat were associated with different outcomes," said Professor Chavarro. "One advantage of assisted reproduction as a model for the study of human fertility is that it allows the examination of factors possibly related to interactions between the embryo and the endometrium independently of other factors related to early embryo development or ovarian response to stimulation.
"Different types of fat are known to have different effects on biological processes which may influence the outcome of assisted reproduction - such as underlying levels of inflammation or insulin sensitivity. However, it is not clear at this moment which biological mechanisms underlie the associations we found."On the question of recommendations to IVF patients, Professor Chavarro said: "While these results are interesting, this is the first time to our knowledge that dietary fats have been linked to treatment outcome in IVF. So it is important that our results are replicated in other studies before making strong recommendations about fat intake to women having infertility treatment."
Note: When obtaining outside comment, journalists are requested to ensure that their contacts are aware of the embargo on this release.
The 28th Annual Meeting of ESHRE, the world's largest event in reproductive science and medicine, is taking place in Istanbul from 1-4 July 2012
Christine Bauquis | EurekAlert!
Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
08.12.2017 | Event News
07.12.2017 | Event News
05.12.2017 | Event News
08.12.2017 | Life Sciences
08.12.2017 | Information Technology
08.12.2017 | Information Technology