Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New calculations solve an old problem with DNA

21.12.2012
In a recent publication, researchers achieved new accuracy in the ability to measure energy differences between states of molecules, thus predicting which states will be observed: The normal (B-form) DNA will switch to left-handed (Z-form) DNA when it is physically twisted, or when a lot of salt is added to the solution.

Researchers at the University of Luxembourg were able to accurately calculate for the first time the amount of salt which is required to do this. Z-DNA in the cell leads to loss of function and cancer.


The normal (B-form) DNA will switch to left-handed (Z-form) DNA when it is physically twisted, or when a lot of salt is added to the solution. Researchers at the University of Luxembourg were able to accurately calculate for the first time the amount of salt which is required to do this.
Josh Berryman

It has been known since the seventies that excessive salt causes DNA to reverse its twist, from a right-handed spiral to a left-handed one. DNA in the Z form is treated by our natural repair enzymes as damaged, and is therefore usually deleted from the cell. Deletion of genetic material can lead to cancer or to other problems, so the B-Z transition is no mere curiosity. However such is the complexity of the DNA molecule that a theoretical explanation which correctly predicts the amount of salt to do this has never before been found.

Dr. Josh Berryman and Professor Tanja Schilling of the University of Luxembourg have now been able to find a method of calculation which predicts this transition with unprecedented accuracy. With this success in describing the most enigmatic of molecules, the team is optimistic that they will be able to perform similar mathematical analyses for a variety of other substances.

... more about:
»B-form »DNA »DNA molecule »Z-form »energy differences

"It will enable us to predict material properties such as melting temperatures or elasticity. And this will be done with high accuracy using our new technique. Hence, we can now design new materials and biomaterials on the computer more effectively than before," said Prof. Schilling.

Prof Schilling and Dr Berryman are physicists at the University’s Physics and Material Sciences Research Unit, which comprises a team of 50 researchers.

The paper entitled “Free Energies by Thermodynamic Integration Relative to an Exact Solution, Used to Find the Handedness-Switching Salt Concentration for DNA” was published in the Journal of Chemical Theory and Computation.

Britta Schlüter | idw
Further information:
http://www.uni.lu
http://pubs.acs.org/doi/abs/10.1021/ct3005968

Further reports about: B-form DNA DNA molecule Z-form energy differences

More articles from Physics and Astronomy:

nachricht Further Improvement of Qubit Lifetime for Quantum Computers
09.12.2016 | Forschungszentrum Jülich

nachricht Electron highway inside crystal
09.12.2016 | Julius-Maximilians-Universität Würzburg

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>