Medical physicists at Thomas Jefferson University and Jefferson's Kimmel Cancer Center are one step closer to bringing a new tumor-tracking technique into the clinic that delivers higher levels of radiation to moving tumors, while sparing healthy tissue in lung cancer patients.
Evidence has shown a survival advantage for lung cancer patients treated with higher doses of radiation. Therefore, there is an increased interest to find novel ways to better track tumors—which are in constant motion because of breathing—in order to up the dosage during radiation therapy without increasing harmful side effects
After proving its success in simulations, researchers have now shown that their real-time tracking technique can achieve such tasks. Not only can it better predict and track tumor motion and deliver higher levels of radiation to lung cancer patients and others with moving tumor targets, it can also successfully be implemented into existing clinical equipment (i.e., Elekta Precise Table).
The results of the study, led by Ivan Buzurovic, Ph.D., a medical physics resident and researcher in the Department of Radiation Oncology at Thomas Jefferson University, and Yan Yu, Ph.D., Professor, Vice Chair and Director of Medical Physics at Thomas Jefferson University, were published in the November issue of Medical Physics.
"We've shown here that our system can better predict and continuously track moving tumors during radiotherapy, preventing unnecessary amounts of radiation from being administered to unnecessary areas," said Dr. Buzurovic. "Just as important, we've successfully modified existing technology to integrate with the system to perform the tracking and delivery, meaning no additional robotic systems is needed."
Respiratory and cardiac motions have been found to displace and deform tumors in the lung and other organs. Because of this, radiation oncologists must expand the margin during radiotherapy, and consequently a large volume of healthy tissue is irradiated, and critical organs adjacent to the tumor are sometimes difficult to spare.
In an effort to shrink that margin, Jefferson researchers developed a new, robotic technique that better tracks tumor motion to deliver more precise radiation.
Here, the researchers applied a new control system (software and hardware) and robotic technology to existing treatment couches used for radiation therapy to determine the tracking technology's feasibility in a clinical setting.
They found the technology can be integrated onto treatment couches and validated the tumor tracking system capabilities to follow desired trajectories. When the active tracking system was applied, irradiated planning target volume (the area set for treatment) was 20 to 30 percent less for medium size tumors and more than 50 percent for small size tumors.
"The use of tumor tracking technology during radiotherapy treatment for lung cancer would result in significant reduction in dose to critical organs and tissue, potentially decreasing the probability or severity of side effects, and thus improving cancer treatments," Dr. Yu said.
Based on these results, it can be hypothesized that clinical implementation of real-time tracking is feasible for achieving potentially improved patient outcome.
"With this new technique, it shrinks the margin, and radiation oncologists would be able to administer more radiation and faster to the tumor than conventional methods," said Adam P. Dicker, M.D, Ph.D., Professor and Chairman of the Department of Radiation Oncology at Thomas Jefferson University. "And a higher, more targeted dose means a better cure in lung cancer."
Steve Graff | EurekAlert!
Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn
New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology
Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.
Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...
With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.
Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...
At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.
In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...
27.09.2016 | Event News
23.09.2016 | Event News
20.09.2016 | Event News
27.09.2016 | Life Sciences
27.09.2016 | Physics and Astronomy
27.09.2016 | Life Sciences