Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Unlocking the Brain's Secrets Using Sound

Potential applications include treatments for epilepsy and blindness

The brain is a reclusive organ. Neurons – the cells that make up the brain, nerves, and spinal cord – communicate with each other using electrical pulses known as action potentials, but their interactions are complicated and hard to understand.

Just getting access to the brain itself is difficult: inserting devices through the skull into the brain requires surgery. But work by Technion Professors Eitan Kimmel and Shy Shoham, and Ph.D. student Misha Plaksin, may advance our ability to unlock the brain's secrets noninvasively using sound, and perhaps create new treatments for illnesses. The findings were published today (January 21, 2014) in Physical Review X (

Scientists have known for a while that ultrasonic waves can affect cells in many ways. For instance, physicians use ultrasound to stimulate the production of blood vessels and bone; it's also used in heat therapy. When applied to neurons, ultrasonic waves can change how the neurons generate and transmit electrical signals. "Ultrasound is known to do all kinds of things in cells," says Prof. Kimmel, "but how it works in many cases isn't clear, particularly when it comes to neural stimulation."

A new model may help clarify much of this behavior. This new way of understanding the interaction of sound waves and cells relies on the cellular membrane. This microscopic structure is the skin that surrounds a cell, keeping the organelles – like the nucleus and the DNA it contains – in, and the rest of the world out. The molecules that form the membrane are arranged in such a way that there are two layers, with a space between them. According to Kimmel's model, when the ultrasonic waves encounter a cell, the two layers of the cellular membrane begin to vibrate (much like how a person's vocal cords vibrate when air passes through the larynx). Cell membranes also act as capacitors, storing electrical charge. As the layers vibrate, the membrane's electrical charge also moves, creating an alternating current that leads to a charge accumulation. The longer the vibrations continue, the more charge builds up in the membrane. Eventually, enough charge builds up that an action potential is created.

The Technion team was able to use the model to predict experimental results that were then verified using brain stimulation experiments performed in mice by a team at Stanford University. According to Prof. Shoham, this is "the first predictive theory of ultrasound stimulation." All of these results mean that scientists might be on the verge of finally understanding how ultrasound affects nerve cells.

And this new understanding could lead to important new medical advances. For example, scientists could use ultrasonic waves to probe the brain's internal structure, a non-invasive technique that would be safer than implanting electrodes and complement the information produced by MRI scans. Physicians could also conceivably use ultrasound to treat epileptic seizures. And Shoham has begun studying the ways in which ultrasonic waves could stimulate cells in the retina, possibly creating images and letting people see without light. “There is great potential for additional applications,” says Kimmel.

The Technion team's findings also illustrate how important it is to get a theoretical understanding of things in nature. After all, says Shoham, "there's only so much you can do with effects you don't understand."

Professors Eitan Kimmel and Shy Shoham are members of the Faculty of Biomedical Engineering, and the Russell Berrie Nanotechnology Institute at the Technion-Israel Institute of Technology.

The Technion-Israel Institute of Technology is a major source of the innovation and brainpower that drives the Israeli economy, and a key to Israel’s renown as the world’s “Start-Up Nation.” Its three Nobel Prize winners exemplify academic excellence. Technion people, ideas and inventions make immeasurable contributions to the world including life-saving medicine, sustainable energy, computer science, water conservation and nanotechnology. The Joan and Irwin Jacobs Technion-Cornell Innovation Institute is a vital component of Cornell NYC Tech, and a model for graduate applied science education that is expected to transform New York City’s economy.

American Technion Society (ATS) donors provide critical support for the Technion—more than $1.9 billion since its inception in 1940. Based in New York City, the ATS and its network of chapters across the U.S. provide funds for scholarships, fellowships, faculty recruitment and chairs, research, buildings, laboratories, classrooms and dormitories, and more.

Kevin Hattori | Newswise
Further information:

More articles from Medical Engineering:

nachricht Gentle sensors for diagnosing brain disorders
29.09.2016 | King Abdullah University of Science and Technology

nachricht New imaging technique in Alzheimer’s disease - opens up possibilities for new drug development
28.09.2016 | Lund University

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>