Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study of Fruit Fly MicroRNA Unravels Clues to Aging Process

06.02.2014
Diseases like Alzheimer’s and Huntington’s are often associated with aging, but the biological link between the two is less certain. Researchers at Rutgers University–Camden are seeking insight into this connection by studying very small RNA molecules in the common fruit fly.

“As the flies in our experiment age, we’re able to detect specific patterns of microRNAs — which help to regulate genes — when they are bound to specific proteins,” says Ammar Naqvi, a doctoral student in computational and integrative biology at Rutgers–Camden.

Naqvi, a Philadelphia resident, explains that microRNAs are connected to various developmental stages and disease states, and their proper modulation is required for the integrity and maintenance of cells.

The research is being done under the supervision of Andrey Grigoriev, a professor of biology at Rutgers–Camden, and in collaboration with a research team at the University of Pennsylvania. Computational and bioinformatics analysis for the project is performed at Rutgers–Camden.

In flies, microRNAs are “loaded” onto one of two protein complexes known as Ago1 or Ago2, which then guide it to repress gene expression. The team found that as fruit flies age, more microRNAs accumulate on the Ago2 protein complex, and therefore impact age-associated events in the flies.

“We were able to connect the two processes,” Naqvi says. “Studies have shown that there is some change in the microRNA population with age, but no one was sure how they were partitioned with the protein complexes. We observed such partitioning and also an increase in neurodegeneration, which resulted in a shorter lifespan for these flies.”

Grigoriev explains, “Neurodegeneration and aging go hand-in-hand, but we are the first to have shown the details of this change in regulation with aging. This tells us that there are different mechanisms of regulation in different stages of development. Is aging a byproduct of development? I cannot tell you. It’s possible that this could be relevant for other diseases. That’s what we want to find out.”

The study was recently published in a leading journal in the field, Genes and Development.

Naqvi, who is originally from Long Island, New York, received his bachelor’s degree from Rochester Institute of Technology and his master’s degree from George Mason University. He is the recipient of the prestigious Rutgers Presidential Fellowship, annually awarded to select doctoral students throughout the university to help fund research.

Grigoriev, a Medford resident, earned his bachelor’s and master’s degrees in physics from the Moscow Engineering Physics Institute in Russia. He received his doctoral degree in molecular biology from the Institute of Genetics and Selection of Industrial Microorganisms in Russia.

Rutgers–Camden’s Center for Computational and Integrative Biology combines science and math to better understand how biological systems work.

Ed Moorhouse
856-225-6759
ejmoor@camden.rutgers.edu

Ed Moorhouse | EurekAlert!
Further information:
http://www.rutgers.edu

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>