Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Scientists Research New Way to Battle Bacteria

Scientists at the SUNY College of Environmental Science and Forestry (ESF) are developing a biochemical process that uses a protein molecule to disrupt the process by which bacteria become virulent, a finding that could have widespread implications for human health.

The work is led by Dr. Christopher Nomura of the college’s Department of Chemistry, who discovered that a simple protein molecule can interrupt the process bacteria use to move, eat, attach to surfaces, and communicate with one another or, in other words, to become potentially harmful.

“This is fundamentally a new way to think about blocking bacteria from becoming virulent,” Nomura said.

Exposing bacteria to the synthetic protein disrupts the developmental sequence that is common among such organisms, he said. This gives the process the potential to work against an array of bacteria including those that threaten patients with certain illnesses, such as cystic fibrosis, stubborn strains that commonly affect hospital patients and strains that occur in desert environments and prove troublesome for U.S. troops serving in Afghanistan or similar arid environments.

The college is seeking to patent the process.

Nomura’s research group focuses on the synthesis and properties of eco-friendly, biologically based materials, in particular the production of biobased polymers that can be used to make biodegradable plastics. He and his postdoctoral researcher, Dr. Benjamin Lundgren, were working on experiments in that realm when they overproduced some proteins that they thought would increase the expression of genes to produce the bioplastic materials. But instead of making the bacteria produce large quantities of plastics, the protein had the opposite effect.

Nomura began to investigate the chemistry behind the startling development and discovered that specific proteins can attach themselves to the bacterial DNA in a manner that essentially prevents the organism from expressing the information contained within its genes and results in short circuiting the ability of bacteria to respond to changes in their environment.

The antimicrobial process has an added advantage over traditional antibiotics currently in use: It will be extremely difficult for bacteria to do an end run around the process by simply mutating. Since the protein targets hundreds of genes simultaneously, a corresponding mutation would also involve hundreds of changes. Traditional antibiotics attack only one aspect of the bacteria’s development, making mutation a simpler task.

“Basically, we’re interrupting the flow of genetic information in the cell, in effect ‘hacking’ the program of the bacterial cell,” Nomura said. “If we can fundamentally control the mechanism of gene expression, we can control what the bacteria are capable of doing. We can prevent them from becoming virulent.”

Claire B. Dunn | Newswise
Further information:

More articles from Life Sciences:

nachricht How Does Friendly Fire Happen in the Pancreas?
21.10.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Strong, steady forces at work during cell division
20.10.2016 | University of Massachusetts at Amherst

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Innovative technique for shaping light could solve bandwidth crunch

20.10.2016 | Physics and Astronomy

Finding the lightest superdeformed triaxial atomic nucleus

20.10.2016 | Physics and Astronomy

NASA's MAVEN mission observes ups and downs of water escape from Mars

20.10.2016 | Physics and Astronomy

More VideoLinks >>>