Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists find bone-marrow environment that helps produce infection-fighting T and B cells

25.02.2013
The Children's Medical Center Research Institute at UT Southwestern has deepened the understanding of the environment within bone marrow that nurtures stem cells, this time identifying the biological setting for specialized blood-forming cells that produce the infection-fighting white blood cells known as T cells and B cells.

The research found that cells called early lymphoid progenitors, which are responsible for producing T cells and B cells, thrive in an environment known as an osteoblastic niche. The investigation, published online today in Nature and led by Dr. Sean Morrison, also establishes a promising approach for scientists to map the entire blood-forming system.

Scientists already know how to manufacture large quantities of stem cells that give rise to the nervous system, skin, and other tissues. But they have been unable to make blood-forming stem cells in a laboratory, in part because of a lack of understanding about the niche in which blood-forming stem cells and other progenitor cells reside in the body.

"We believe this research moves us one step closer toward the development of cell therapies in the blood-forming system that don't exist today," said Dr. Morrison, Director of the Institute and Professor of Pediatrics at UT Southwestern Medical Center. "In understanding the environments for blood-forming stem cells and those of different kinds of progenitor cells, we can work toward reproducing those environments in the lab and growing cells that can be transplanted to treat a host of medical conditions."

These findings eventually may help increase the safety and effectiveness of bone-marrow transplants, such as those needed after healthy marrow is destroyed by radiation or chemotherapy treatments for childhood leukemia, Dr. Morrison said. The findings also may have implications for treating illnesses associated with loss of infection-fighting cells, such as HIV and severe combined immunodeficiency disease, better known as bubble boy disease.

The Nature study augments earlier work by Dr. Morrison and his team that showed endothelial cells and perivascular cells lining the blood vessels in the bone marrow create the environment that maintains haematopoietic stem cells, which produce billions of new blood cells every day. The latest study shows that bone-forming cells create the environment that maintains early lymphoid progenitors.

"Our research documents that there are different niches, or microenvironments, for blood-forming stem cells and restricted progenitors in the bone marrow," Dr. Morrison said. "One way that bone marrow makes different kinds of blood-forming cells is by compartmentalizing them into different neighborhoods within the marrow."

The researchers identified niches for stem cells and early lymphoid progenitors by determining which cells are the sources of a growth factor (CXCL12) necessary for the proliferation of those two populations of blood-forming cells. By taking the same approach for other growth factors in the bone marrow, researchers should be able to map the niches for every kind of blood-forming progenitor cell in the bone marrow, Dr. Morrison said.

The UTSW paper's first author is Dr. Lei Ding, a former postdoctoral research fellow at the Children's Research Institute and the Howard Hughes Medical Institute (HHMI) at UT Southwestern. Dr. Ding is now an assistant professor at Columbia University.

Research support came from the HHMI and the National Heart, Lung, and Blood Institute.

About the Children's Research Institute

Children's Medical Center Research Institute at UT Southwestern (CRI) is a joint venture positioned to build upon the comprehensive clinical expertise of Children's Medical Center and the internationally recognized scientific environment of UT Southwestern Medical Center. CRI's mission is to perform transformative biomedical research to better understand the biological basis of disease. Established in 2011, CRI is creating interdisciplinary groups of exceptional scientists and physicians to pursue research at the interface of regenerative medicine, cancer biology and metabolism, which together hold unusual potential for discoveries that can yield groundbreaking advances in science and medicine.

This news release is available on our World Wide Web home page at www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via email, subscribe at www.utsouthwestern.edu/receivenews

Jeff Carlton | EurekAlert!
Further information:
http://www.utsouthwestern.edu

More articles from Life Sciences:

nachricht The first genome of a coral reef fish
29.09.2016 | King Abdullah University of Science and Technology

nachricht New switch decides between genome repair and death of cells
27.09.2016 | University of Cologne - Universität zu Köln

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

HLF: From an experiment to an establishment

29.09.2016 | Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

 
Latest News

New Multiferroic Materials from Building Blocks

29.09.2016 | Materials Sciences

Silicon Fluorescent Material Developed Enabling Observations under a Bright “Biological Optical Window”

29.09.2016 | Materials Sciences

X-shape Bio-inspired Structures

29.09.2016 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>