Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The Nanobioengineering Laboratory Leads The Nanometric Scale Research Of A European Project Focused On The Differentiation Of St

23.07.2004


The director of the Nanobioengineering Laboratory of the CREBEC and sub-director of the Parc Científic de Barcelona (PCB, Barcelona Science Park), Josep Samitier, will coordinate the research lines on the application of nanobiotechnologies for the differentiation of stem cells in the European project entitled CellPROM, the most funded project in the first call of the VI Framework Programme. Josep Samitier will preside the CellPROM Scientific Committee on Nanotechnologies and will join its Management Committee, together with the coordinator of basic research, Andreas Manz, and the coordinator of CellPROM, Gunter Führ, from the Fraunhofer Institut Biomedizinische Technik.

In addition, the Nanobioengineering Laboratory also coordinates the broadest line of research in the project, accounting for 34% of the scientific effort, which focuses on the development of artificial surfaces that allow the controlled differentiation of stem cells whilst simultaneously minimizing their rejection once implanted in the patient.

The project is based on the premise that stem cells can be differentiated through interactions that take place at the cell surface. The final objective of CellPROM is to develop technologies with therapeutic applications in the field of the so-called tissue engineering by applying the tools provided by nanotechnology and the know-how on the differentiation of adult stem cells. Specifically, by producing cell cultures and tissues that can be used for auto-transplants, the project will allow Europe to lead the development in the new medical technology required to use stem cells for regenerative therapies.



At present, regenerative therapies are underway that, for example, use bone marrow-derived adult stem cells cultured in the laboratory, which are then implanted. CellPROM will develop surfaces that mimic biological ones, on which stem cells can be cultured through molecular signals that facilitate a more precise differentiation into the cells of interest.

Furthermore, the resulting cell cultures can also be used as alternatives to assays that involve experimental animals. These advances will have practical applications in the fields of new medical technology and in the biotechnology, pharmaceutical and agroalimentary sectors.

The final outcome of CellPROM will be a prototype that cannot be used in humans until it has passed the clinical trial phases, which will be started shortly.
The project includes the participation of 27 institutions from 12 European countries, which include prestigious institutes and centres such as the PasteurInstitute in France, the Royal Institute of Technology of Sweden, the University of Vienna and the Institute of Pharmaceutical Technology of Austria, the Swiss Federal Institute of Technology, Lausanne, the Fraunhofer Society of Germany and the University of Barcelona, through the Nanobioengineering Laboratory.

The CellPROM project has a total budget of more than 26 million Euros, 17.6 million of which have been granted by the European Commission. The project was officially presented in Saarbrücken, Germany, on 25 and 26 March 2004.

Rosina Malagrida | alfa
Further information:
http://www.pcb.ub.es

More articles from Life Sciences:

nachricht Genetic Regulation of the Thymus Function Identified
23.08.2016 | Universität Basel

nachricht Sun protection for plants - Plant substances can protect plants against harmful UV radiation
22.08.2016 | Max-Planck-Institut für Molekulare Pflanzenphysiologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: X-ray optics on a chip

Waveguides are widely used for filtering, confining, guiding, coupling or splitting beams of visible light. However, creating waveguides that could do the same for X-rays has posed tremendous challenges in fabrication, so they are still only in an early stage of development.

In the latest issue of Acta Crystallographica Section A: Foundations and Advances , Sarah Hoffmann-Urlaub and Tim Salditt report the fabrication and testing of...

Im Focus: Piggyback battery for microchips: TU Graz researchers develop new battery concept

Electrochemists at TU Graz have managed to use monocrystalline semiconductor silicon as an active storage electrode in lithium batteries. This enables an integrated power supply to be made for microchips with a rechargeable battery.

Small electrical gadgets, such as mobile phones, tablets or notebooks, are indispensable accompaniments of everyday life. Integrated circuits in the interiors...

Im Focus: UCI physicists confirm possible discovery of fifth force of nature

Light particle could be key to understanding dark matter in universe

Recent findings indicating the possible discovery of a previously unknown subatomic particle may be evidence of a fifth fundamental force of nature, according...

Im Focus: Wi-fi from lasers

White light from lasers demonstrates data speeds of up to 2 GB/s

A nanocrystalline material that rapidly makes white light out of blue light has been developed by KAUST researchers.

Im Focus: Every atom counts

Malignant cancer cells not only proliferate faster than most body cells. They are also more dependent on the most important cellular garbage disposal unit, the proteasome, which degrades defective proteins. Therapies for some types of cancer exploit this dependence: Patients are treated with inhibitors, which block the proteasome. The ensuing pile-up of junk overwhelms the cancer cell, ultimately killing it. Scientists have now succeeded in determining the human proteasome’s 3D structure in unprecedented detail and have deciphered the mechanism by which inhibitors block the proteasome. Their results will pave the way to develop more effective proteasome inhibitors for cancer therapy.

In order to understand how cellular machines such as the proteasome work, it is essential to determine their three-dimensional structure in detail. With its...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

A week of excellence: 22 of the world’s best computer scientists and mathematicians in Heidelberg

12.08.2016 | Event News

Towards the connected, automated and electrified automobiles: AMAA conference in Brussels

02.08.2016 | Event News

Clash of Realities 2016: 7th Conference on the Art, Technology and Theory of Digital Games

29.07.2016 | Event News

 
Latest News

New microchip demonstrates efficiency and scalable design

23.08.2016 | Information Technology

Genetic Regulation of the Thymus Function Identified

23.08.2016 | Life Sciences

Biomass turnover time in ecosystems is halved by land use

23.08.2016 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>